LONG-ACTING SUSTAINED-RELEASE PREPARATION CONTAINING PRAMIPEXOLE AND PREPARATION METHOD THEREFOR

Title:

LONG-ACTING SUSTAINED-RELEASE PREPARATION CONTAINING PRAMIPEXOLE AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2023/221814

Kind Code:

A1

Abstract:

Disclosed is a long-acting sustained-release preparation pharmaceutical composition containing pramipexole, comprising a pharmaceutically acceptable salt of pramipexole and a pharmaceutical high polymer material. The preparation is selected from a microsphere, a sustained-release particle, and a subcutaneous implant. The pharmaceutically acceptable salt of pramipexole is selected from erucate, stearate, oleate, α-linolenate, heptadecanoate, embonate, and palmitate. The high polymer material is selected from PLGA, PLA, mPEG-PLA, and PEG-PLA-PEG. The present invention belongs to the technical field of pharmaceutical preparations and solves the problems of short release period and poor release effect of pramipexole in the prior art.

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Inventors:

SU ZHENGXING (CN)
DING DUOHAO (CN)
CHEN ZHIHAO (CN)
ZHAO DONG (CN)

Application Number:

PCT/CN2023/092960

Publication Date:

November 23, 2023

Filing Date:

May 09, 2023

Export Citation:

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Assignee:

SICHUAN KELUN PHARM RES INST CO LTD (CN)

International Classes:

A61K9/16; A61K9/52; A61K31/428; A61K47/32; A61K47/34; A61P25/16

Foreign References:

CN111728956A	2020-10-02
US20170014353A1	2017-01-19
CN103432104A	2013-12-11

Other References:

"Thesis", 25 March 2019, NIRMA UNIVERSITY, India, article CHAUDHARY K V: "Development and Analysis of Long Acting Parenteral Formulation", XP009550768
KOMAL CHAUDHARY, DHARA BHAYANI, SANDEEP SHAH, SHANTANU DHARMADHIKARI, PRITI MEHTA J.: "Dissolution-Controlled Salt of Pramipexole for Parenteral Administration: In Vitro Assessment and Mathematical Modeling", DISSOLUTION TECHNOLOGIES, DISSOLUTION TECHNOLOGIES, SHAWNEE MISSION, KS, US, vol. 26, no. 1, 1 January 2019 (2019-01-01), US , pages 28 - 35, XP093111049, ISSN: 1521-298X, DOI: 10.14227/DT260119P28

Attorney, Agent or Firm:

NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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