Title:
LONG-CHAIN COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045985
Kind Code:
A1
Abstract:
Disclosed are a long-chain compound and the use thereof. The structure of the long-chain compound is as shown in formula (I). The compound can directly inhibit ACLY, has a significant therapeutic effect on metabolic diseases represented by hypercholesterolemia and non-alcoholic steatohepatitis, and can be used for developing and preparing therapeutic drugs for metabolic diseases such as hypercholesterolemia and non-alcoholic steatohepatitis.
Inventors:
NAN FAJUN (CN)
LI JINGYA (CN)
ZHANG MEI (CN)
XIE ZHIFU (CN)
ZHANG YANGMING (CN)
LI JINGYA (CN)
ZHANG MEI (CN)
XIE ZHIFU (CN)
ZHANG YANGMING (CN)
Application Number:
PCT/CN2022/120315
Publication Date:
March 30, 2023
Filing Date:
September 21, 2022
Export Citation:
Assignee:
BURGEON THERAPEUTICS CO LTD (CN)
International Classes:
A61K31/201; A61K31/194; A61P3/00; A61P3/06; A61P9/10; C07C55/21; C07C55/28; C07C57/13
Domestic Patent References:
| WO2021021563A1 | 2021-02-04 |
Foreign References:
| CN107118098A | 2017-09-01 | |||
| CN101677982A | 2010-03-24 | |||
| US4634795A | 1987-01-06 | |||
| US4711896A | 1987-12-08 | |||
| CN110054562A | 2019-07-26 | |||
| CN201610105067A | 2016-02-25 | |||
| CN107118098A | 2017-09-01 |
Other References:
PINKOSKY STEPHEN L., NEWTON ROGER S., DAY EMILY A., FORD REBECCA J., LHOTAK SARKA, AUSTIN RICHARD C., BIRCH CAROLYN M., SMITH BREN: "Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis", NATURE COMMUNICATIONS, vol. 7, no. 1, 28 November 2016 (2016-11-28), XP093053582, DOI: 10.1038/ncomms13457
YANG, WEILI ET AL.,: "A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol,", PNAS, vol. 107, no. 26, 29 June 2010 (2010-06-29), XP055581252, DOI: 10.1073/pnas.0914149107
DATABASE REGISTRY ANONYMOUS : "INDEX NAME NOT YET ASSIGNED", XP093053595, retrieved from STN
JOSHUA P. SAMSOONDAR, AMY C. BURKE, BRIAN G. SUTHERLAND, DAWN E. TELFORD, CYNTHIA G. SAWYEZ, JANE Y. EDWARDS, STEPHEN L. PINKOSKY,: "Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr −/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic AcidHighlights", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 37, no. 4, 1 April 2017 (2017-04-01), pages 647 - 656, XP055413415, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.116.308963
XIE ZHIFU, ZHANG MEI, SONG QIAN, CHENG LONG, ZHANG XINWEN, SONG GAOLEI, SUN XINYU, GU MIN, ZHOU CHENDONG, ZHANG YANGMING, ZHU KEXI: "Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia", ACTA PHARMACEUTICA SINICA B, vol. 13, no. 2, 1 February 2023 (2023-02-01), pages 739 - 753, XP093053588, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2022.06.011
SONG GAO‐LEI, CAO LEI, ZHANG MEI, YANG YU‐ROU, MA JIE, XIE ZHI‐FU, LI JING‐YA, NAN FA‐JUN: "Discovery of Novel Long-Chain Alkenyl Diacid Derivatives as ACLY Inhibitors", CHINESE JOURNAL OF CHEMISTRY, ZHONGGUO KEXUEYUAN, CN, vol. 40, no. 22, 1 August 2022 (2022-08-01), CN , pages 2663 - 2670, XP093053592, ISSN: 1001-604X, DOI: 10.1002/cjoc.202200362
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
YANG, WEILI ET AL.,: "A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol,", PNAS, vol. 107, no. 26, 29 June 2010 (2010-06-29), XP055581252, DOI: 10.1073/pnas.0914149107
DATABASE REGISTRY ANONYMOUS : "INDEX NAME NOT YET ASSIGNED", XP093053595, retrieved from STN
JOSHUA P. SAMSOONDAR, AMY C. BURKE, BRIAN G. SUTHERLAND, DAWN E. TELFORD, CYNTHIA G. SAWYEZ, JANE Y. EDWARDS, STEPHEN L. PINKOSKY,: "Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr −/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic AcidHighlights", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 37, no. 4, 1 April 2017 (2017-04-01), pages 647 - 656, XP055413415, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.116.308963
XIE ZHIFU, ZHANG MEI, SONG QIAN, CHENG LONG, ZHANG XINWEN, SONG GAOLEI, SUN XINYU, GU MIN, ZHOU CHENDONG, ZHANG YANGMING, ZHU KEXI: "Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia", ACTA PHARMACEUTICA SINICA B, vol. 13, no. 2, 1 February 2023 (2023-02-01), pages 739 - 753, XP093053588, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2022.06.011
SONG GAO‐LEI, CAO LEI, ZHANG MEI, YANG YU‐ROU, MA JIE, XIE ZHI‐FU, LI JING‐YA, NAN FA‐JUN: "Discovery of Novel Long-Chain Alkenyl Diacid Derivatives as ACLY Inhibitors", CHINESE JOURNAL OF CHEMISTRY, ZHONGGUO KEXUEYUAN, CN, vol. 40, no. 22, 1 August 2022 (2022-08-01), CN , pages 2663 - 2670, XP093053592, ISSN: 1001-604X, DOI: 10.1002/cjoc.202200362
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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