LONG TERM ANTIMICROBIAL ADDITIVES UTILIZING ALKALINE EARTH SALTS OF SULFONAMIDE COMPOUNDS

CROSS-REFERENCE TO RELATED APPLICATIONS

This Application claims the benefit of prior filed U.S. Application number 63/133,066, filed December 31 , 2020, and incorporates the same by reference herein in its entirety.

FIELD OF THE INVENTION

The present invention relates to the field of medicine and more particularly relates to various structures, including implants and prosthetics, which are impregnated

BACKGROUND OF THE INVENTION

There is a need in the dental and medical industry to provide long-term antimicrobial compounds that can be added to various materials and compositions utilized in many procedures and operations where infection control is critically desired.

The present invention utilizes the insoluble salts of sulfonamides as an additive in various compositions and materials to provide a long-term anti-microbial presence where it is needed. The present invention represents a departure from the prior art in that prosthetics of the present invention present long-term anti-microbial activity within the body.

SUMMARY OF THE INVENTION

In view of the foregoing disadvantages inherent in the known types of prosthetics, an improved prosthetic may provide antimicrobial protection by utilizing sulfonamide compounded impregnated within the body of the prosthetic.

The more notable features of the invention have thus been outlined in order that the more detailed description that follows may be better understood and in order that the present contribution to the art may better be appreciated. Additional features of the invention will be described hereinafter and will form the subject matter of the claims that follow.

Many objects of this invention will appear from the following description and appended claims, reference being made to the accompanying drawings forming a part of this specification wherein like reference characters designate corresponding parts in the several views.

Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangements of the components set forth in the following description or illustrated in the drawings. The invention is capable of other embodiments and of being practiced and carried out in several ways. Also, it is to be understood that the phraseology and terminology employed herein are for description and should not be regarded as limiting.

As such, those skilled in the art will appreciate that the conception, upon which this disclosure is based, may readily be utilized as a basis for the designing of other structures, methods, and systems for carrying out the several purposes of the present invention. It is important, therefore, that the claims be regarded as including such equivalent constructions as far as they do not depart from the spirit and scope of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS

The Figure is a schematic of a sulfonamide backbone, for use in the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

With reference now to the drawings, a preferred embodiment of the antimicrobial additives and their use are herein described. It should be noted that the articles “a,” “an,” and “the,” as used in this specification, include plural referents unless the content clearly dictates otherwise. With reference to the Figure, the present invention utilizes the class of antimicrobial/antibiotics known as sulfonamides in its broadest sense to include all derivatives that can be derived from the Sulfonamide backbone of the Figure, where R1 , R2, R3 represent any moiety.

Examples of sulfonamides include but are not limited to sulfanilamide, sulfadiazine, bumetamide, torsemide, acetazolamide, glibenclamide, sulfasalazine, hydrochlorothiazide, furosemide, sulfamethoxyazole, indapamide, metalozone, and any other sulfonamide derivative. The preferred sulfonamide of the present invention is sulfadiazine.

To achieve a long-term presence of sulfonamides in compositions and materials the antibiotic must be water insoluble, especially at the pH of physiological fluids. The second requirement for long term antimicrobial materials and compositions that are placed within a physiological body is biocompatibility.

The present invention utilizes the alkaline earth elements: beryllium, magnesium, calcium, strontium, and barium to form water insoluble salts with sulfonamides that are naturally biocompatible with physiological systems found in the body. The preferred salt for insolubility is the barium salts of sulfonamides. The preferred salt for biocompatibility is the calcium salts of sulfonamides. The most preferred salt is the calcium salts of sulfonamides because it provides the best balance of insolubility and biocompatibility of all the alkaline earth salts. Of these alkaline earth sulfonamides, calcium sulfadiazine.

The prior art utilizes salts of sulfonamides such as sodium, potassium, silver, and zinc. Potassium and sodium sulfonamide salts are semi-soluble in water and thus have no long-term viability when embedded in materials or compositions. Silver and zinc salts are both physiologically toxic and are not intended for long term contact with biological organisms. The purpose of utilizing silver and zinc salts of sulfonamides of the prior art is precisely because of the additional toxicity these salts provide to the antimicrobial activity of sulfonamides; and are therefore designed for short term contact

The alkaline earth sulfonamides of the present invention are designed to have long term contact with biological organisms, such as the human body. They are intended to be in contact with the human body for up to about 6 months to a year, or a permanent placement where it is desired.

The alkaline earth sulfonamides of the present invention can be embedded in various materials and compositions such as: coatings, resins, plastics, adhesives, cements, paints, prosthetics, films, polymers, fillers, elastomers, gels, and any other material or composition designed for long term contact with biological organisms as a structure. A “structure” as it is defined within this Specification, shall include any resultant product, device, repair, or prosthetic created from the use, curing, or manufacture of these products.

An example of the present invention blends alkaline earth sulfonamides with elastomeric resin that can be applied as a coating material and then cured into an elastomeric solid as a thin layer over a prosthetic designed to be permanently implanted within a human body.

An example of the present invention blends alkaline earth sulfonamides with dental resins, cements, adhesives, and composites that are then utilized to repair carious teeth; such that they provide long term antimicrobial activity at the repair margins and inhibit the further progression of caries.

An example of the present invention compounds alkaline earth sulfonamides into polymers and plastics that are then extrudes as long-term antimicrobial film.

An example of the present invention compounds alkaline earth sulfonamides into polymers and plastics that are then formed by various means known in the art into an implantable prosthetic.

An example of the present invention provides alkaline earth sulfonamides as a filler additive for applications such as paint that are intended to provide long term antimicrobial activity.

INDUSTRIAL APPLICABILITY

The material described herein may be manufactured through various industrial processes and have wide applicability in the medical and dental fields. Although the present invention has been described with reference to preferred embodiments, numerous modifications and variations can be made and still the result will come within the scope of the invention. No limitation with respect to the specific embodiments disclosed herein is intended or should be inferred.