Title:
LOW-MOLECULAR-WEIGHT-COMPOUND ADJUVANT AND VACCINE USING SAME
Document Type and Number:
WIPO Patent Application WO/2017/170712
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a chemosynthetic adjuvant for selectively inducing TSLP. The present invention provides a vaccine adjuvant including a RAR γ agonist, and a vaccine obtained by combining the vaccine adjuvant and an antigen.
Inventors:
HIRASAWA NORIYASU (JP)
Application Number:
PCT/JP2017/012937
Publication Date:
October 05, 2017
Filing Date:
March 29, 2017
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K39/39; A61K39/00; A61K39/02; A61K39/12; A61K39/145; A61P31/04; A61P31/12; A61P31/16; A61P31/18; A61P33/02; A61P33/06; A61P35/00
Domestic Patent References:
| WO2016021601A1 | 2016-02-11 | |||
| WO2001078700A2 | 2001-10-25 | |||
| WO2011051657A1 | 2011-05-05 |
Foreign References:
| JP2011500733A | 2011-01-06 |
Other References:
MARTIN MARIA DEL P. ET AL.: "Adjuvanted Influenza Vaccine Administered Intradermally Elicits Robust Long-Term Immune Responses that Confer Protection from Lethal Challenge", PLOS ONE, vol. 5, no. 5, 2010, pages e10897, XP055429093
TAN LIBO ET AL.: "Oral Vitamin A and Retinoic Acid Supplementation Stimulates Antibody Production and Splenic Stra6 Expression in Tetanus Toxoid-Immunized Mice", THE JOURNAL OF NUTRITION, vol. 142, 2012, pages 1590 - 1595, XP055429096
WATSON DOUGLAS S. ET AL.: "All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A", IMMUNOLOGY AND CELL BIOLOGY, vol. 87, 2009, pages 630 - 633, XP055429101
GOETTSCH WIM ET AL.: "ADJUVANT ACTIVITY OF LL- TRANS-RETINOIC ACID IN C57B1/6 MICE", INT. J. IMMUNOPHARMAC., vol. 14, no. 2, 1992, pages 143 - 150, XP025491640
MIHALY JOHANNA ET AL.: "TSLP expression in the skin is mediated via RARy-RXR pathways", IMMUNOBIOLOGY, vol. 221, 10 September 2015 (2015-09-10), pages 161 - 165, XP029347202
TAKAHIRO HATAYAMA ET AL.: "Retinoic Acid ni yoru TSLP Hatsugen Seigyo Kiko no Kaiseki", PROCEEDINGS OF THE ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 136, 26 March 2016 (2016-03-26)
TAN LIBO ET AL.: "Oral Vitamin A and Retinoic Acid Supplementation Stimulates Antibody Production and Splenic Stra6 Expression in Tetanus Toxoid-Immunized Mice", THE JOURNAL OF NUTRITION, vol. 142, 2012, pages 1590 - 1595, XP055429096
WATSON DOUGLAS S. ET AL.: "All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A", IMMUNOLOGY AND CELL BIOLOGY, vol. 87, 2009, pages 630 - 633, XP055429101
GOETTSCH WIM ET AL.: "ADJUVANT ACTIVITY OF LL- TRANS-RETINOIC ACID IN C57B1/6 MICE", INT. J. IMMUNOPHARMAC., vol. 14, no. 2, 1992, pages 143 - 150, XP025491640
MIHALY JOHANNA ET AL.: "TSLP expression in the skin is mediated via RARy-RXR pathways", IMMUNOBIOLOGY, vol. 221, 10 September 2015 (2015-09-10), pages 161 - 165, XP029347202
TAKAHIRO HATAYAMA ET AL.: "Retinoic Acid ni yoru TSLP Hatsugen Seigyo Kiko no Kaiseki", PROCEEDINGS OF THE ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 136, 26 March 2016 (2016-03-26)
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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