Title:
LPA RECEPTOR AGONISTS AND ANTAGONISTS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2003024402
Kind Code:
A3
Abstract:
The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
Inventors:
MILLER DUANE D
TIGYI GABOR
DALTON JAMES T
SARDAR VINEET M
ELROD DON B
XU HUIPING
BAKER DANIEL L
WANG DEAN
LILIOM KAROLY
FISCHER DAVID J
VIRAG TAMAS
NUSSER NORA
TIGYI GABOR
DALTON JAMES T
SARDAR VINEET M
ELROD DON B
XU HUIPING
BAKER DANIEL L
WANG DEAN
LILIOM KAROLY
FISCHER DAVID J
VIRAG TAMAS
NUSSER NORA
Application Number:
PCT/US2002/029593
Publication Date:
February 19, 2004
Filing Date:
September 17, 2002
Export Citation:
Assignee:
UNIV TENNESSEE RES CORP (US)
International Classes:
A61K31/27; A61K31/66; A61K31/683; A61K31/661; A61P1/00; A61P9/00; A61P9/10; A61P13/08; A61P15/00; A61P17/00; A61P17/02; A61P17/14; A61P35/00; A61P43/00; C07C237/06; C07C237/08; C07C271/22; C07F9/09; C07F9/11; C07F9/17; C07F9/22; C07F9/38; C07F9/40; (IPC1-7): A61K31/66; A61K31/07; A61K47/00
Domestic Patent References:
| WO1998041213A1 | 1998-09-24 |
Foreign References:
| US5565439A | 1996-10-15 | |||
| US5480877A | 1996-01-02 |
Other References:
See also references of EP 1427424A4
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