Title:
LPA RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2004/031118
Kind Code:
A1
Abstract:
Compounds represented by the following general formula (I) and nontoxic salts thereof: (I) wherein each symbol is as defined in the description. Because of binding to LPA receptors and antagonizing the same, the compounds represented by the general formula (I) are useful in preventing and/or treating urinary diseases (symptoms accompanying prostate-gland enlargement or neurogenic bladder disease, symptoms caused by spinal tumor, herniated disk, vertebral canal stenosis or diabetes, lower urinary tract obstruction, lower urinary tract inflammatory disease, polyuria), cancer-related diseases (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi’s sarcoma, leukemia, infiltrative metastasis of cancer), proliferative diseases (diseases accompanied by abnormal angiogenesis, arterial occlusion, pulmonary fibrosis), inflammatory immune diseases (psoriasis, nephropathy, hepatitis, pulmonary inflammation), diseases caused by secretion failures (Sjoegren’s syndrome), brain-related diseases (cerebral infarction, cerebral hemorrhage, cerebral or peripheral neuropathy), or chronic diseases (chronic asthma, glomerular nephritis, obesity, prostate-gland enlargement, diseases caused by the progress of arteriosclerosis, rheumatoid and atopic dermatitis).
Inventors:
TERAKADO MASAHIKO (JP)
NAKADE SHINJI (JP)
SEKO TAKUYA (JP)
TAKAOKA YOSHIKAZU (JP)
NAKADE SHINJI (JP)
SEKO TAKUYA (JP)
TAKAOKA YOSHIKAZU (JP)
Application Number:
PCT/JP2003/006680
Publication Date:
April 15, 2004
Filing Date:
May 28, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TERAKADO MASAHIKO (JP)
NAKADE SHINJI (JP)
SEKO TAKUYA (JP)
TAKAOKA YOSHIKAZU (JP)
TERAKADO MASAHIKO (JP)
NAKADE SHINJI (JP)
SEKO TAKUYA (JP)
TAKAOKA YOSHIKAZU (JP)
International Classes:
A61K31/192; A61K31/216; A61K31/402; A61K31/4035; A61K31/404; A61K31/41; A61K31/4184; A61K31/4402; A61K31/445; A61K31/472; A61K31/517; A61K31/5415; C07C65/40; C07C235/52; (IPC1-7): C07C65/40; A61K31/192; A61K31/216; A61K31/402; A61K31/4035; A61K31/404; A61K31/41; A61K31/4184; A61K31/4402; A61K31/445; A61K31/472; A61K31/517; A61K31/5415; C07C235/52
Domestic Patent References:
| WO2002029001A2 | 2002-04-11 | |||
| WO1995012572A1 | 1995-05-11 | |||
| WO1993012095A1 | 1993-06-24 | |||
| WO2002062798A2 | 2002-08-15 | |||
| WO1999008501A2 | 1999-02-25 | |||
| WO2002000646A1 | 2002-01-03 | |||
| WO2001000206A1 | 2001-01-04 | |||
| WO2002062389A1 | 2002-08-15 | |||
| WO2001060819A1 | 2001-08-23 |
Foreign References:
| EP0341081A2 | 1989-11-08 | |||
| JPS5690067A | 1981-07-21 | |||
| JPH11158144A | 1999-06-15 | |||
| JPH10287634A | 1998-10-27 | |||
| EP0573271A1 | 1993-12-08 | |||
| EP0390215A2 | 1990-10-03 | |||
| GB112166A | 1917-12-28 | |||
| US2868691A | 1959-01-13 | |||
| US3095355A | 1963-06-25 |
Other References:
See also references of EP 1553075A4
MOL PHARMACOL, vol. 58, no. 6, December 2000 (2000-12-01), pages 1188 - 96
AM. J. PHYSIOL. LUNG CELL MOL. PHYSIOL., vol. 282, no. 1, 2002, pages L91
CLIN. SCIENCE, vol. 96, 1999, pages 431
J. CLIN. INVEST., vol. 101, 1998, pages 1431
AM. J. PHYSIOL., vol. 267, no. 36, 1994, pages C204
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, WILEY
MOL PHARMACOL, vol. 58, no. 6, December 2000 (2000-12-01), pages 1188 - 96
AM. J. PHYSIOL. LUNG CELL MOL. PHYSIOL., vol. 282, no. 1, 2002, pages L91
CLIN. SCIENCE, vol. 96, 1999, pages 431
J. CLIN. INVEST., vol. 101, 1998, pages 1431
AM. J. PHYSIOL., vol. 267, no. 36, 1994, pages C204
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, WILEY
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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