Title:
LUMINOGENS FOR BIOLOGICAL APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2018/108070
Kind Code:
A1
Abstract:
A compound comprises a donor and an acceptor, wherein at least one donor ( "D" ) and at least one acceptor ( "A" ) may be arranged in an order of D-A; D-A-D; A-D-A; D-D-A-D-D; A-A-D-A-A; D-A-D-A-D; and A-D-A-D-A. The compound may be selected from the group consisting of: MTPE-TP, MTPE-TT, TPE-TPA-TT, PTZ-BT-TPA, NPB-TQ, TPE-TQ-A, MTPE-BTSe, DCDPP-2TPA, DCDPP-2TPA4M, DCDP-2TPA, DCDP-2TPA4M, TTS, ROpen-DTE-TPECM, and RClosed-DTE-TPECM. The compound may be used as a probe and may be functionalized with special targeted groups to image biological species. As non-limiting examples, the compound may be used in cellular cytoplasms or tissue imaging, blood vessel imaging, in vivo fluorescence imaging, brain vascular imaging, sentinel lymph node mapping, and tumor imaging, and the compound may be used as a photoacoustic agent.
More Like This:
WO/2021/014437 | PROCESS FOR THE PREPARATION OF BIPHENYLAMINES |
WO/1993/000903 | USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS |
JP2022550640 | Aryl heterocycles as Kv1.3 potassium Shaker channel blockers |
Inventors:
TANG BENZHONG (CN)
QI JI (CN)
CHEN MING (CN)
QIN WEI (CN)
ZHANG PENGFEI (CN)
QI JI (CN)
CHEN MING (CN)
QIN WEI (CN)
ZHANG PENGFEI (CN)
Application Number:
PCT/CN2017/115629
Publication Date:
June 21, 2018
Filing Date:
December 12, 2017
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
C07D241/24; C07D487/02; C07D513/02; C07D515/02; C07D517/02; C09K11/00; H01L51/50
Foreign References:
CN106831650A | 2017-06-13 |
Other References:
ISHI-I, T. ET AL.: "Light-emitting properties of donor-acceptor and donor-acceptor-donor dyes in solution, solid, and aggregated states: structure-property relationship of emission behavior", RSC ADVANCES, vol. 5, no. 108, 14 October 2015 (2015-10-14), pages 89171 - 89187, XP055493729
MCNAMARA, L.E. ET AL.: "Donor-Acceptor-Donor Thienopyrazines via Pd-Catalyzed C-H Activation as NIR Fluorescent Materials", J.ORG.CHEM., vol. 81, no. 1, 24 November 2015 (2015-11-24), pages 32 - 42, XP055493734
LU , X. ET AL.: "Controlling the Charge Transfer in D-A-D Chromophores Based on Pyrazine Derivatives", J.ORG.CHEM., vol. 79, no. 14, 20 June 2014 (2014-06-20), pages 6480 - 6489, XP055332517
KONO, T. ET AL.: "Synthesis and photo-electrochemical properties of novel thienopyrazine and quinoxaline derivatives, and their dye-sensitized solar cell performance", ORGANIC ELECTRONICS, vol. 13, no. 12, December 2012 (2012-12-01), pages 3097 - 3101, XP055493738
KATO, S. ET AL.: "Strongly red-fluorescent novel donor-p-bridge-acceptor-p-bridge- donor (D-p-A-p-D) type 2,1,3-benzothiadiazoles with enhanced two-photon absorption cross- sections", CHEM. COMMUN., no. 20, 7 September 2004 (2004-09-07), pages 2342 - 2343, XP055493741
QIAN, G. ET AL.: "Synthesis and Application of Thiadiazoloquinoxaline-Containing Chromophores as Dopants for Efficient Near-Infrared Organic Light-Emitting Diodes", J. PHYS. CHEM. C., vol. 113, no. 4, 7 January 2009 (2009-01-07), pages 1589 - 1595, XP055115044
QIAN, G. ET AL.: "Simple and Efficient Near-Infrared Organic Chromophores for Light- Emitting Diodes with Single Electroluminescent Emission above 1000nm", ADV. MATER, vol. 21, no. 1, 31 December 2009 (2009-12-31), pages 111 - 116, XP055493744
MCNAMARA, L.E. ET AL.: "Donor-Acceptor-Donor Thienopyrazines via Pd-Catalyzed C-H Activation as NIR Fluorescent Materials", J.ORG.CHEM., vol. 81, no. 1, 24 November 2015 (2015-11-24), pages 32 - 42, XP055493734
LU , X. ET AL.: "Controlling the Charge Transfer in D-A-D Chromophores Based on Pyrazine Derivatives", J.ORG.CHEM., vol. 79, no. 14, 20 June 2014 (2014-06-20), pages 6480 - 6489, XP055332517
KONO, T. ET AL.: "Synthesis and photo-electrochemical properties of novel thienopyrazine and quinoxaline derivatives, and their dye-sensitized solar cell performance", ORGANIC ELECTRONICS, vol. 13, no. 12, December 2012 (2012-12-01), pages 3097 - 3101, XP055493738
KATO, S. ET AL.: "Strongly red-fluorescent novel donor-p-bridge-acceptor-p-bridge- donor (D-p-A-p-D) type 2,1,3-benzothiadiazoles with enhanced two-photon absorption cross- sections", CHEM. COMMUN., no. 20, 7 September 2004 (2004-09-07), pages 2342 - 2343, XP055493741
QIAN, G. ET AL.: "Synthesis and Application of Thiadiazoloquinoxaline-Containing Chromophores as Dopants for Efficient Near-Infrared Organic Light-Emitting Diodes", J. PHYS. CHEM. C., vol. 113, no. 4, 7 January 2009 (2009-01-07), pages 1589 - 1595, XP055115044
QIAN, G. ET AL.: "Simple and Efficient Near-Infrared Organic Chromophores for Light- Emitting Diodes with Single Electroluminescent Emission above 1000nm", ADV. MATER, vol. 21, no. 1, 31 December 2009 (2009-12-31), pages 111 - 116, XP055493744
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
Download PDF:
Previous Patent: DISPLAY DEVICE AND MANUFACTURING METHOD THEREFOR
Next Patent: METHOD AND DEVICE FOR SELECTING FORWARDING PATH
Next Patent: METHOD AND DEVICE FOR SELECTING FORWARDING PATH