Title:
LUMINOUS COMPOUNDS AND LABELING REAGENTS USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2003/033447
Kind Code:
A1
Abstract:
Compounds represented by the following general formula (I): R−Y−(−X−Phe−COCH2COCnF2n&plus 1)m (I) wherein R represents hydrogen, alkyl, phenyl or a group capable of binding to a protein, a peptide, an amino acid, a nucleic acid or a base&semi Y represents CH2, a carbon ring or a heterocycle&semi X represents O, S, NH, CH2, OCH2, CONH or NHCO&semi Phe represents phenylene&semi n is an integer of from 1 to 5&semi and m is 1, 2 or 3&semi luminous complexes comprising the above compounds with rare earth ions&semi labeling reagents comprising the compounds or luminous complexes as described above&semi and a method of labeling a protein, a peptide, an amino acid, a nucleic acid or a base using the above labeling reagents.
Inventors:
SAITO MICHIHIRO (JP)
PRETSCH ERNOE (CH)
PRETSCH ERNOE (CH)
Application Number:
PCT/JP2002/010511
Publication Date:
April 24, 2003
Filing Date:
October 10, 2002
Export Citation:
Assignee:
HITACHI HIGH TECH CORP (JP)
SAITO MICHIHIRO (JP)
PRETSCH ERNOE (CH)
SAITO MICHIHIRO (JP)
PRETSCH ERNOE (CH)
International Classes:
C07C45/45; C07C45/46; C07C45/68; C07C45/71; C07C49/80; C07C49/813; C07C49/84; C07C225/22; C07C323/22; C07D233/60; C07D333/24; (IPC1-7): C07C49/813; C07C49/84; C07C233/61; C07C225/22; C07C323/22; C07D233/60; G01N33/533
Foreign References:
| EP0794174A2 | 1997-09-10 |
Other References:
DAS M. & HAWORTH D.T.: "Dipole moments of some beta-diketones and monothio-beta-diketones", SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, vol. 25, no. 5, 1995, pages 845 - 857, XP002961725
PASHKEVICH K.I. ET AL.: "Synthesis and structure of fluorine-containing beta-chlorovinyl ketones", IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA, no. 9, 1986, pages 2125 - 2127, XP002961726
UHLEMANN E. ET AL.: "Liquid-liquid extraction of gallium with bidentate ligands", ANALYTICA CHIMICA ACTA, vol. 130, no. 1, 1981, pages 177 - 182, XP002961727
BAXTER A.J.G. ET AL.: "Azoalkene route to methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: synthesis of 1-(BOC-amino)pyrrole-3-carboxylates and their conversion to 1H-pyrroles via 1-aminopyrroles", SYNTHESIS, no. 2, 1994, pages 207 - 211, XP002028877
See also references of EP 1437338A4
PASHKEVICH K.I. ET AL.: "Synthesis and structure of fluorine-containing beta-chlorovinyl ketones", IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA, no. 9, 1986, pages 2125 - 2127, XP002961726
UHLEMANN E. ET AL.: "Liquid-liquid extraction of gallium with bidentate ligands", ANALYTICA CHIMICA ACTA, vol. 130, no. 1, 1981, pages 177 - 182, XP002961727
BAXTER A.J.G. ET AL.: "Azoalkene route to methyl 2,5-dimethyl-4-(2-(phenylmethyl)benzoyl)-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: synthesis of 1-(BOC-amino)pyrrole-3-carboxylates and their conversion to 1H-pyrroles via 1-aminopyrroles", SYNTHESIS, no. 2, 1994, pages 207 - 211, XP002028877
See also references of EP 1437338A4
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chom, Minato-ku Tokyo, JP)
Download PDF: