Title:
LUNG CANCER BIOMARKERS
Document Type and Number:
WIPO Patent Application WO/2011/015602
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for detecting, managing or monitoring cancer. The invention also relates to antibodies specific for cancer markers, compositions and chips containing the same, as well as their uses for cancer detection, managing, monitoring, imaging or treatment, as well as for drug development. The invention is particularly suited for detecting, managing or monitoring lung cancer in human subjects.
Inventors:
GUERGOVA-KURAS MARIANA (FR)
KURUCZ ISTVAN (HU)
KADAS JANOS (HU)
HEMPEL WILLIAM (FR)
TARDIEU NADEGE (FR)
MALDERES-BLOES CAROLE (FR)
JULLIEN ANNE (FR)
KIEFFER YANN (FR)
TAKACS LASZLO (FR)
KURUCZ ISTVAN (HU)
KADAS JANOS (HU)
HEMPEL WILLIAM (FR)
TARDIEU NADEGE (FR)
MALDERES-BLOES CAROLE (FR)
JULLIEN ANNE (FR)
KIEFFER YANN (FR)
TAKACS LASZLO (FR)
Application Number:
PCT/EP2010/061354
Publication Date:
May 26, 2011
Filing Date:
August 04, 2010
Export Citation:
Assignee:
BIOSYSTEMS INTERNAT SAS (FR)
GUERGOVA-KURAS MARIANA (FR)
KURUCZ ISTVAN (HU)
KADAS JANOS (HU)
HEMPEL WILLIAM (FR)
TARDIEU NADEGE (FR)
MALDERES-BLOES CAROLE (FR)
JULLIEN ANNE (FR)
KIEFFER YANN (FR)
TAKACS LASZLO (FR)
GUERGOVA-KURAS MARIANA (FR)
KURUCZ ISTVAN (HU)
KADAS JANOS (HU)
HEMPEL WILLIAM (FR)
TARDIEU NADEGE (FR)
MALDERES-BLOES CAROLE (FR)
JULLIEN ANNE (FR)
KIEFFER YANN (FR)
TAKACS LASZLO (FR)
International Classes:
C07K16/30; G01N33/50
Domestic Patent References:
| WO2008114917A1 | 2008-09-25 | |||
| WO2007047796A2 | 2007-04-26 |
Foreign References:
| US20090035875A1 | 2009-02-05 |
Other References:
OKANO TETSUYA ET AL: "Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis.", PROTEOMICS JUL 2006 LNKD- PUBMED:16767791, vol. 6, no. 13, July 2006 (2006-07-01), pages 3938 - 3948, XP009140370, ISSN: 1615-9853
HEO SUN-HEE ET AL: "Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS.", PROTEOMICS DEC 2007 LNKD- PUBMED:17963278, vol. 7, no. 23, December 2007 (2007-12-01), pages 4292 - 4302, XP009140371, ISSN: 1615-9853
WEIVODA S ET AL: "ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL LNKD- DOI:10.1016/J.JIM.2008.03.004, vol. 336, no. 1, 20 July 2008 (2008-07-20), pages 22 - 29, XP022682287, ISSN: 0022-1759, [retrieved on 20080404]
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; April 1983 (1983-04-01), TAKADA K ET AL: "[Complement components, whole complement activity, and circulating immune complexes in neoplastic diseases].", XP002630003, Database accession no. NLM6602233
MORGAN B P ET AL: "Immunoradiometric assay for human complement component C9 utilising monoclonal antibodies", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 134, no. 1-2, 31 October 1983 (1983-10-31), pages 85 - 94, XP023396301, ISSN: 0009-8981, [retrieved on 19831031], DOI: DOI:10.1016/0009-8981(83)90187-0
HOAGLAND LUKE F M 4TH ET AL: "Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer.", CANCER 15 NOV 2007 LNKD- PUBMED:17918261, vol. 110, no. 10, 15 November 2007 (2007-11-15), pages 2260 - 2268, XP009140372, ISSN: 0008-543X
YEE JOHN ET AL: "Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 10 JUN 2009 LNKD- PUBMED:19414677, vol. 27, no. 17, 10 June 2009 (2009-06-10), pages 2787 - 2792, XP009140373, ISSN: 1527-7755
See also references of EP 2462164A2
HEO SUN-HEE ET AL: "Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS.", PROTEOMICS DEC 2007 LNKD- PUBMED:17963278, vol. 7, no. 23, December 2007 (2007-12-01), pages 4292 - 4302, XP009140371, ISSN: 1615-9853
WEIVODA S ET AL: "ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL LNKD- DOI:10.1016/J.JIM.2008.03.004, vol. 336, no. 1, 20 July 2008 (2008-07-20), pages 22 - 29, XP022682287, ISSN: 0022-1759, [retrieved on 20080404]
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; April 1983 (1983-04-01), TAKADA K ET AL: "[Complement components, whole complement activity, and circulating immune complexes in neoplastic diseases].", XP002630003, Database accession no. NLM6602233
MORGAN B P ET AL: "Immunoradiometric assay for human complement component C9 utilising monoclonal antibodies", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 134, no. 1-2, 31 October 1983 (1983-10-31), pages 85 - 94, XP023396301, ISSN: 0009-8981, [retrieved on 19831031], DOI: DOI:10.1016/0009-8981(83)90187-0
HOAGLAND LUKE F M 4TH ET AL: "Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer.", CANCER 15 NOV 2007 LNKD- PUBMED:17918261, vol. 110, no. 10, 15 November 2007 (2007-11-15), pages 2260 - 2268, XP009140372, ISSN: 0008-543X
YEE JOHN ET AL: "Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 10 JUN 2009 LNKD- PUBMED:19414677, vol. 27, no. 17, 10 June 2009 (2009-06-10), pages 2787 - 2792, XP009140373, ISSN: 1527-7755
See also references of EP 2462164A2
Attorney, Agent or Firm:
BECKER, Philippe et al. (25 rue Louis Le Grand, Paris, FR)
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