Title:
LUNG CANCER DETECTION METHOD AND DETECTION KIT
Document Type and Number:
WIPO Patent Application WO/2017/199817
Kind Code:
A1
Abstract:
Lung cancer can be detected by measuring sites in pancreatic ribonuclease 1 (also abbreviated as "RNase 1"), wherein each of the sites is a site capable of being modified with an N-linked sugar chain.
Lung cancer is detected by measuring items A and B as mentioned below and then comparing the ratio of the value of A to the value of B: A = the amount of sites in pancreatic ribonuclease 1, wherein the sites are sites each capable of being modified with an N-linked sugar chain and each having an N-linked sugar chain bound thereto or each having an N-linked sugar chain unbound thereto; and B = the amount of sites in pancreatic ribonuclease 1, wherein the sites are sites each capable of being modified with an N-linked sugar chain.
Inventors:
NAKATA DAISUKE (JP)
Application Number:
PCT/JP2017/017723
Publication Date:
November 23, 2017
Filing Date:
May 10, 2017
Export Citation:
Assignee:
TOSOH CORP (JP)
International Classes:
G01N33/574; C12N9/16
Domestic Patent References:
| WO2013187371A1 | 2013-12-19 |
Foreign References:
| JP2016042083A | 2016-03-31 | |||
| JP2015172583A | 2015-10-01 |
Other References:
NAKATA, D. ET AL.: "Increased N-glycosylaton of Asn88 in serum pancreatic ribonuclease 1 is a novel diagnostic marker for pancreatic cancer", SCIENTIFIC REPORTS, vol. 4, no. 6715, 22 October 2014 (2014-10-22), pages 1 - 8, XP055232102
MAKOTO NAKAYAMA ET AL.: "Haigan Kanja Kessei Oyobi Kyosuichu Ribonuclease(RNase) Kassei Sokutei no Rinshoteki Igi ni Kansuru Kento", JAPANESE JOURNAL OF LUNG CANCER, vol. 23, no. 3, 1983, pages 403, XP009516855, Retrieved from the Internet
BARRABES, S. ET AL.: "Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer", GLYCOBIOLOGY, vol. 17, no. 4, 2007, pages 388 - 400, XP002638711
See also references of EP 3467503A4
MAKOTO NAKAYAMA ET AL.: "Haigan Kanja Kessei Oyobi Kyosuichu Ribonuclease(RNase) Kassei Sokutei no Rinshoteki Igi ni Kansuru Kento", JAPANESE JOURNAL OF LUNG CANCER, vol. 23, no. 3, 1983, pages 403, XP009516855, Retrieved from the Internet
BARRABES, S. ET AL.: "Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer", GLYCOBIOLOGY, vol. 17, no. 4, 2007, pages 388 - 400, XP002638711
See also references of EP 3467503A4
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