Title:
LUNG CANCER DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/225830
Kind Code:
A1
Abstract:
Provided is a lung adenocarcinoma detection method that is simple and is less invasive. The lung adenocarcinoma detection method of the present invention includes the step of detecting the presence or absence of an abnormal cleavage in kininogen I in a sample collected from a subject in vitro. The abnormal cleavage in kininogen I is, for example, a cleavage that can form at least one cleaved site in a peptide bond in kininogen I and/or a cleavage that causes the deletion of at least one amino acid residue at at least one site in kininogen I. The lung adenocarcinoma detection method according to the present invention includes the step of detecting the presence or amount of a protein having the above-mentioned abnormal cleavage or the loss of the amount of a normal protein, and the like.
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Inventors:
NAKAZATO MASAMITSU (JP)
MATSUMOTO NOBUHIRO (JP)
TSUBOUCHI HIRONOBU (JP)
ARIMURA YASUJI (JP)
YANAGI SHIGEHISA (JP)
TAKAO TOSHIFUMI (JP)
OKUMURA NOBUAKI (JP)
MATSUMOTO NOBUHIRO (JP)
TSUBOUCHI HIRONOBU (JP)
ARIMURA YASUJI (JP)
YANAGI SHIGEHISA (JP)
TAKAO TOSHIFUMI (JP)
OKUMURA NOBUAKI (JP)
Application Number:
PCT/JP2018/021901
Publication Date:
December 13, 2018
Filing Date:
June 07, 2018
Export Citation:
Assignee:
UNIV MIYAZAKI (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
G01N33/574; G01N33/53
Foreign References:
| JP2015105951A | 2015-06-08 | |||
| JP2016505137A | 2016-02-18 | |||
| US20150147765A1 | 2015-05-28 | |||
| US20100008935A1 | 2010-01-14 | |||
| JP2012526976W | ||||
| JP2014115186A | 2014-06-26 |
Other References:
KITABATA, HIROKI: "Angiotensin-1-converting enzyme (ACE)", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 62, no. 11, 28 November 2004 (2004-11-28), pages 499 - 501, XP009518196, ISSN: 0047-1852
MUNOZ, MIGUEL: "The Substance P/neurokinin-1 receptor system in lung cancer: Focus on the antitumor action of neurokinin-1 receptor antagonist", PEPTIDES, vol. 38, no. 2, December 2012 (2012-12-01), pages 318 - 325, XP055219145
CHAN D, ET AL.: "Bradykinin antagonist dimer , CU 201, inhibits the growth of human lung cancer cell lines by a ''biased agonist'' mechanism", PROC NATL ACAD SCI USA, vol. 99, no. 7, 2 April 2002 (2002-04-02), pages 4608 - 4613, XP055564526
KOSHIRO, MASATAKA: "Movements of Fibrinopeptide A (FPA), Fibrinopeptide Bbeta15-42 (PPBbeta), Factor XII, and Prekallikrein in blood with respect to malignant tumor", MEDICAL JOURNAL OF KAGOSHIMA UNIVERSITY, vol. 40, no. 1, 1988, pages 17 - 24, XP009518207, ISSN: 0368-5063
SAWABATA N ET AL., J THORAC ONCOL., vol. 6, 2011, pages 1229 - 35
ATAGI S ET AL., LANCET ONCOL., vol. 13, 2012, pages 671 - 8
SCAGLIOTTI GV ET AL., J CLIN ONCOL., vol. 26, 2008, pages 3543 - 51
MOLINA R ET AL., AM J RESPIR CRIT CARE MED., vol. 193, 2016, pages 427 - 37
MATSUOKA K ET AL., EUR J CARDIOTHORAC SURG., vol. 32, 2007, pages 435 - 9
RASTEL D ET AL., EUR J CANCER, vol. 30A, 1994, pages 601 - 6
STIEBER P ET AL., ANTICANCER RES., vol. 19, no. 4A, 1999, pages 2673 - 8
FERNANDEZ-DE-COSSIO J.TAKAO T. ET AL., RAPID COMMUN. MASS SPECTROM., vol. 18, 2004, pages 2465 - 2472
See also references of EP 3637106A4
MUNOZ, MIGUEL: "The Substance P/neurokinin-1 receptor system in lung cancer: Focus on the antitumor action of neurokinin-1 receptor antagonist", PEPTIDES, vol. 38, no. 2, December 2012 (2012-12-01), pages 318 - 325, XP055219145
CHAN D, ET AL.: "Bradykinin antagonist dimer , CU 201, inhibits the growth of human lung cancer cell lines by a ''biased agonist'' mechanism", PROC NATL ACAD SCI USA, vol. 99, no. 7, 2 April 2002 (2002-04-02), pages 4608 - 4613, XP055564526
KOSHIRO, MASATAKA: "Movements of Fibrinopeptide A (FPA), Fibrinopeptide Bbeta15-42 (PPBbeta), Factor XII, and Prekallikrein in blood with respect to malignant tumor", MEDICAL JOURNAL OF KAGOSHIMA UNIVERSITY, vol. 40, no. 1, 1988, pages 17 - 24, XP009518207, ISSN: 0368-5063
SAWABATA N ET AL., J THORAC ONCOL., vol. 6, 2011, pages 1229 - 35
ATAGI S ET AL., LANCET ONCOL., vol. 13, 2012, pages 671 - 8
SCAGLIOTTI GV ET AL., J CLIN ONCOL., vol. 26, 2008, pages 3543 - 51
MOLINA R ET AL., AM J RESPIR CRIT CARE MED., vol. 193, 2016, pages 427 - 37
MATSUOKA K ET AL., EUR J CARDIOTHORAC SURG., vol. 32, 2007, pages 435 - 9
RASTEL D ET AL., EUR J CANCER, vol. 30A, 1994, pages 601 - 6
STIEBER P ET AL., ANTICANCER RES., vol. 19, no. 4A, 1999, pages 2673 - 8
FERNANDEZ-DE-COSSIO J.TAKAO T. ET AL., RAPID COMMUN. MASS SPECTROM., vol. 18, 2004, pages 2465 - 2472
See also references of EP 3637106A4
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
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