Title:
LXR MODULATORS
Document Type and Number:
WIPO Patent Application WO2000054759
Kind Code:
A3
Abstract:
The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compositions find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.
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Inventors:
LI LEPING
MEDINA JULIO C
HASEGAWA HIROHIKO
CUTLER SERENA T
LIU JIWEN
ZHU LIUSHENG
SHAN BEI
LUSTIG KEVIN
MEDINA JULIO C
HASEGAWA HIROHIKO
CUTLER SERENA T
LIU JIWEN
ZHU LIUSHENG
SHAN BEI
LUSTIG KEVIN
Application Number:
PCT/US2000/006611
Publication Date:
February 15, 2001
Filing Date:
March 15, 2000
Export Citation:
Assignee:
TULARIK INC (US)
International Classes:
C07D295/10; A61K31/136; A61K31/167; A61K31/17; A61K31/18; A61K31/192; A61K31/196; A61K31/235; A61K31/24; A61K31/27; A61K31/277; A61K31/351; A61K31/381; A61K31/40; A61K31/404; A61K31/4164; A61K31/4188; A61K31/42; A61K31/4245; A61K31/426; A61K31/429; A61K31/433; A61K31/4406; A61K31/4436; A61K31/47; A61K31/472; A61K31/5375; A61K31/538; A61K31/5415; A61K31/55; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P19/10; A61P25/30; C07C233/60; C07C233/75; C07C235/42; C07C271/28; C07C271/58; C07C275/32; C07C307/10; C07C311/08; C07C311/21; C07C311/29; C07C311/44; C07C317/14; C07D209/04; C07D209/08; C07D213/71; C07D215/36; C07D215/58; C07D223/16; C07D261/10; C07D265/36; C07D271/08; C07D271/12; C07D277/20; C07D277/54; C07D279/02; C07D285/14; C07D295/185; C07D295/20; C07D295/215; C07D309/14; C07D333/34; C07D333/40; C07D333/42; C07D409/04; C07D409/12; C07D413/12; C07D513/04; (IPC1-7): A61K31/18; A61K31/167; A61K31/17; A61K31/24; A61K31/27; A61K31/277; A61K31/381; C07C311/21; C07D333/34
Domestic Patent References:
| WO2000046203A2 | 2000-08-10 |
Foreign References:
| EP0919542A2 | 1999-06-02 | |||
| US4230635A | 1980-10-28 | |||
| US4093742A | 1978-06-06 | |||
| GB1507340A | 1978-04-12 | |||
| US3281466A | 1966-10-25 | |||
| US4251534A | 1981-02-17 | |||
| US4240979A | 1980-12-23 | |||
| EP0193249A2 | 1986-09-03 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MIRYAN, N. I. ET AL: "Derivatives of pyridinecarboxylic acids. Synthesis and antiexudative effect of fluorinated derivatives of nicotinamide and isonicotinamide", XP002151153, retrieved from STN Database accession no. 86:139798 CA
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; POLISHCHUK, V. R. ET AL: "Electron paramagnetic resonance spectra of 2-arylpolyfluoroisopropyl radicals", XP002151154, retrieved from STN Database accession no. 91:4737 CA
[online] GILBERT, EVERETT E. ET AL: "perhalo ketones - (VI) aromatic amino derivs. of the penhaloacetones", XP002151155, retrieved from STN Database accession no. 16091f
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; POLISHCHUK, V. R. ET AL: "Electron paramagnetic resonance spectra of 2-arylpolyfluoroisopropyl radicals", XP002151154, retrieved from STN Database accession no. 91:4737 CA
[online] GILBERT, EVERETT E. ET AL: "perhalo ketones - (VI) aromatic amino derivs. of the penhaloacetones", XP002151155, retrieved from STN Database accession no. 16091f
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