LYOPHILIZED PREPARATION PROVIDING REVERSIBLY THERMOGELLING WATER-BASE MEDICINAL COMPOSITION

Title:

LYOPHILIZED PREPARATION PROVIDING REVERSIBLY THERMOGELLING WATER-BASE MEDICINAL COMPOSITION

Document Type and Number:

WIPO Patent Application WO/1996/011672

Kind Code:

A1

Abstract:

A lyophilized preparation of a reversibly thermogelling water-base composition comprising an effective dose of a medicine, 0.2 - 2.1 % (w/v) of methylcellulose (containing 26 - 33 % of methoxyl groups), 1.2 - 2.3 % (w/v) of citric acid, and 0.5 - 13 % (w/v) of polyethylene glycol. This preparation serves to keep a moisture-sensitive medicine stable till the time of its use and can be converted into a composition which reversibly gels upon heating when applied to the affected part by adding a suitable amount of a solvent.

Inventors:

TAKEUCHI MASANOBU (JP)
TAKAHASHI HIROE (JP)
TAKAHASHI TOSHIE (JP)
MARUYAMA HIROKI (JP)
FUKUSHIMA MIYAKO (JP)
MASUDA KEIKO (JP)
OGUMA TOURU (JP)
MAEDA MAKOTO (JP)

Application Number:

PCT/JP1994/001709

Publication Date:

April 25, 1996

Filing Date:

October 13, 1994

Export Citation:

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Assignee:

WAKAMOTO PHARMA CO LTD (JP)
TAKEUCHI MASANOBU (JP)
TAKAHASHI HIROE (JP)
TAKAHASHI TOSHIE (JP)
MARUYAMA HIROKI (JP)
FUKUSHIMA MIYAKO (JP)
MASUDA KEIKO (JP)
OGUMA TOURU (JP)
MAEDA MAKOTO (JP)

International Classes:

A61K9/00; A61K9/19; A61K47/00; A61K47/10; A61K47/12; A61K47/38; (IPC1-7): A61K9/14; A61K47/38

Foreign References:

JPS52125619A	1977-10-21
JPS61103825A	1986-05-22

Other References: