Title:
LYOPHILIZED PREPARATION
Document Type and Number:
WIPO Patent Application WO/2018/124277
Kind Code:
A1
Abstract:
[Problem] To provide a pharmaceutical composition that contains a fusion protein of an antibody and a lysosomal enzyme as an active ingredient and is stable enough to be distributed on the market. [Solution] A lyophilized preparation that contains a fusion protein of an antibody and a lysosomal enzyme as an active ingredient, and furthermore contains a neutral salt, a disaccharide, a non-ionic surfactant, and a buffer. An example of such a lyophilized preparation contains a fusion protein of an anti-transferrin receptor antibody and human iduronate-2-sulfatase as an active ingredient, and furthermore contains sodium chloride as a neutral salt, sucrose as a disaccharide, poloxamer as a non-ionic surfactant, and a phosphate buffer as a buffer.
Inventors:
YASUKAWA HIDEHITO (JP)
YAMAGUCHI YUKA (JP)
OKABE SHINJI (JP)
YAMAGUCHI YUKA (JP)
OKABE SHINJI (JP)
Application Number:
PCT/JP2017/047207
Publication Date:
July 05, 2018
Filing Date:
December 28, 2017
Export Citation:
Assignee:
JAPAN CHEM RES (JP)
International Classes:
A61K38/46; A61K9/19; A61K39/395; A61K47/02; A61K47/10; A61K47/26; A61P25/00
Domestic Patent References:
| WO2015098989A1 | 2015-07-02 | |||
| WO2016208696A1 | 2016-12-29 | |||
| WO2015136470A1 | 2015-09-17 | |||
| WO2007074880A1 | 2007-07-05 | |||
| WO2006132363A1 | 2006-12-14 |
Foreign References:
| JP2013530988A | 2013-08-01 | |||
| JP2009540015A | 2009-11-19 | |||
| JP2015163637A | 2015-09-10 | |||
| JP2016185971A | 2016-10-27 | |||
| JP2015509526A | 2015-03-30 | |||
| JP2010534723A | 2010-11-11 | |||
| JP2012521194A | 2012-09-13 | |||
| JP2016519124A | 2016-06-30 | |||
| JP2009540015A | 2009-11-19 | |||
| JP2012501332A | 2012-01-19 | |||
| US20040229250A1 | 2004-11-18 |
Other References:
BOWIE ET AL., SCIENCE, vol. 247, 1990, pages 1306 - 1310
See also references of EP 3563863A4
See also references of EP 3563863A4
Attorney, Agent or Firm:
YAMAMOTO, Yoshiki (JP)
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