Title:
LYSIN-ANTIMICROBIAL PEPTIDE (AMP) POLYPEPTIDE CONSTRUCTS, LYSINS, ISOLATED POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/191633
Kind Code:
A3
Abstract:
The present disclosure is directed to lysin-AMP polypeptide constructs, isolated lysin polypeptides, and pharmaceutical compositions comprising the isolated polypeptides and/or lysin-AMP polypeptide constructs. Methods of using the lysin-AMP polypeptide constructs, isolated lysin polypeptides and pharmaceutical compositions are also herein provided. In addition, isolated polynucleotides encoding the lysin-AMP polypeptide constructs and isolated lysin polypeptides are disclosed herein.
Inventors:
SCHUCH RAYMOND (US)
Application Number:
PCT/US2019/024912
Publication Date:
November 07, 2019
Filing Date:
March 29, 2019
Export Citation:
Assignee:
CONTRAFECT CORP (US)
International Classes:
C12N9/52; A61K38/00; A61K38/16; A61P31/04; C07K14/00; C07K19/00
Foreign References:
| CN102861324A | 2013-01-09 | |||
| KR20130129326A | 2013-11-28 |
Other References:
THANDAR ET AL.: "Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii", ANTIMICROB AGENTS CHEMOTHER, vol. 60, no. 5, 2016, pages 2671 - 2679, XP055650498
DATABASE Protein 5 July 2017 (2017-07-05), "RecName: Full=DNA binding protein ORF8", XP055650506, retrieved from Ncbi Database accession no. J_BPCHP
DATABASE Protein 5 July 2017 (2017-07-05), "RecName: Full=DNA binding protein ORF8", XP055650506, retrieved from Ncbi Database accession no. J_BPCHP
Attorney, Agent or Firm:
PARKER, Linda (US)
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