Title:
LYSINE DECARBOXYLASES HAVING MODIFICATIONS AT TITRATABLE AMINO ACIDS
Document Type and Number:
WIPO Patent Application WO/2018/120025
Kind Code:
A1
Abstract:
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.
Inventors:
CHOU HOWARD (CN)
CHEN LING (CN)
LU WENQIANG (CN)
LIU XIUCAI (CN)
CHEN LING (CN)
LU WENQIANG (CN)
LIU XIUCAI (CN)
Application Number:
PCT/CN2016/113516
Publication Date:
July 05, 2018
Filing Date:
December 30, 2016
Export Citation:
Assignee:
CATHAY R&D CENTER CO LTD (CN)
CATHAY IND BIOTECH LTD (GB)
CATHAY IND BIOTECH LTD (GB)
International Classes:
C12N9/00; C12N1/21; C12N15/00; C12P13/00
Domestic Patent References:
| WO2015196430A1 | 2015-12-30 |
Foreign References:
| EP1482055A1 | 2004-12-01 | |||
| CN104498519A | 2015-04-08 |
Other References:
DATABASE Protein [O] 17 December 2008 (2008-12-17), PUZIO, P. ET AL.: "unnamed protein product [Hafnia alvei]", XP055509604, retrieved from NCBI Database accession no. CAV25914.1
DATABASE Protein [O] 18 December 2003 (2003-12-18), BRETON, G. L. ET AL.: "Sequence 13001 from patent US 6610836", XP055509606, retrieved from NCBI Database accession no. AAR53284.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product[Salmonella enterica subsp. enterica serovar Typhi]", XP055509610, retrieved from NCBI Database accession no. CBA11202.1
DATABASE Protein [O] 25 September 2009 (2009-09-25), PUZIO, P. ET AL.: "unnamed protein product [Vibrio parahaemolyticus]", XP055509613, retrieved from NCBI Database accession no. CBG14132.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Vibrio parahaemolyticus]", XP055509620, retrieved from NCBI Database accession no. CBA11249.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Vibrio vulnificus]", XP055509623, retrieved from NCBI Database accession no. CBA11215.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Vibrio cholerae]", XP055509628, retrieved from NCBI Database accession no. CBA11206.1
DATABASE Protein [O] 25 September 2009 (2009-09-25), PUZIO, P. ET AL.: "unnamed protein product [Vibrio vulnificua]", XP055509633, retrieved from NCBI Database accession no. CBG14138.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Moritella japonica]", XP055509636, retrieved from NCBI Database accession no. CBA11214.1
See also references of EP 3562938A4
DATABASE Protein [O] 18 December 2003 (2003-12-18), BRETON, G. L. ET AL.: "Sequence 13001 from patent US 6610836", XP055509606, retrieved from NCBI Database accession no. AAR53284.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product[Salmonella enterica subsp. enterica serovar Typhi]", XP055509610, retrieved from NCBI Database accession no. CBA11202.1
DATABASE Protein [O] 25 September 2009 (2009-09-25), PUZIO, P. ET AL.: "unnamed protein product [Vibrio parahaemolyticus]", XP055509613, retrieved from NCBI Database accession no. CBG14132.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Vibrio parahaemolyticus]", XP055509620, retrieved from NCBI Database accession no. CBA11249.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Vibrio vulnificus]", XP055509623, retrieved from NCBI Database accession no. CBA11215.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Vibrio cholerae]", XP055509628, retrieved from NCBI Database accession no. CBA11206.1
DATABASE Protein [O] 25 September 2009 (2009-09-25), PUZIO, P. ET AL.: "unnamed protein product [Vibrio vulnificua]", XP055509633, retrieved from NCBI Database accession no. CBG14138.1
DATABASE Protein [O] 28 July 2009 (2009-07-28), PLESCH, G. ET AL.: "unnamed protein product [Moritella japonica]", XP055509636, retrieved from NCBI Database accession no. CBA11214.1
See also references of EP 3562938A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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