Title:
LYSOSOMAL DEGRADATION OF LIPIDS AND PROTEINS AND METHOD OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/008141
Kind Code:
A8
Abstract:
Methods for modulating lysosome-mediated microautophagy of a lipid or protein substrate in a cell are provided herein. In certain embodiments, said methods may comprise increasing lysosome-mediated microautophagy by treating the cell with a microautophagy-enhancing agent which increases lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or increases lysosomal degradation capacity; or decreasing lysosome-mediated microautophagy by treating the cell with a microautophagy-reducing agent which reduces lysosomal association-dissociation events between lysosomes and the cellular lipid or protein substrate and/or decreases lysosomal degradation capacity; thereby modulating lysosome-mediated microautophagy of the lipid or protein substrate.
Inventors:
AMIR ALIPOUR MOHSEN (CA)
YAO ZEMIN (CA)
YAO ZEMIN (CA)
Application Number:
PCT/CA2016/000192
Publication Date:
February 16, 2017
Filing Date:
July 08, 2016
Export Citation:
Assignee:
UNIV OTTAWA (CA)
International Classes:
A61K38/45; A61K31/202; A61K31/7088; A61K38/17; A61K38/46; A61P3/00; A61P3/06; C07K14/47; C12N1/00; C12N5/071
Attorney, Agent or Firm:
SCHROEDER, Hans et al. (CA)
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