M. TUBERCULOSIS VACCINES - STATENS SERUMINSTITUT

Title:

M. TUBERCULOSIS VACCINES

Document Type and Number:

WIPO Patent Application WO/2014/063704

Kind Code:

A8

Abstract:

The present invention is directed to fusion proteins, antigen cocktails and immunological compositions such as vaccines against infections caused by virulent mycobacteria, e.g. by Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium microti, Mycobacterium canettii, Mycobacterium pinnipedii or Mycobacterium mungi. The fusion proteins or antigen cocktails are based on ESX secreted or associated proteins e.g. proteins secreted by the ESAT-6 secretion system 1 (ESX-1 ) which are among the most immunodominant M. tuberculosis (MTB) antigens.

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Inventors:

AAGAARD CLAUS (DK)
ROSENKRANDS IDA (DK)
HOANG TRUC THI KIM THANH (DK)
ANDERSEN PETER (DK)

Application Number:

PCT/DK2013/000070

Publication Date:

July 30, 2015

Filing Date:

October 18, 2013

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Assignee:

STATENS SERUMINSTITUT (DK)

International Classes:

C07K14/35; A61K38/00; A61K39/00

Attorney, Agent or Firm:

TOFT, Lars (Corporate AffairsArtillerivej 5, Copenhagen S, DK)

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