METHOD FOR PREDICTING DIFFERENTIATION POTENCY OF iPS CELLS IN CARTILAGE CELLS USING GENE EXPRESSION PROFILES

WIPO Patent Application WO/2018/225868

A1

Provided is a method for predicting the differentiation potency of iPS cells in cartilage cells at the undifferentiated iPS cell-stage. Also provided is a genetic marker for predicting the differentiation potency of undifferentiated iPS cells in cartilage cells. This method predicts the differentiation potency of undifferentiated iPS cells in cartilage cells on the basis of gene expression data of the undifferentiated iPS cells. The method predicts the differentiation potency of undifferentiated iPS cells in neural crest cells (NC cells) on the basis of gene expression data of the iPS cells, and as a result, predicts the differentiation potency of the undifferentiated iPS cells in cartilage cells.

WATANABE MAKOTO (JP)
SATO TAKA-AKI (JP)
TOGUCHIDA JUNYA (JP)

PCT/JP2018/022116

December 13, 2018

June 08, 2018

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SHIMADZU CORP (JP)
UNIV KYOTO (JP)

C12N15/12; C12N5/077; C12N5/10; C12N15/11; C12Q1/04; C12Q1/6876

JP2013545439A	2013-12-26
JP2016088909A	2016-05-23
JP2016532435A	2016-10-20
JP2009532047A	2009-09-10
JP2016528892A	2016-09-23

DATABASE Nucleotide [O] National Center for Biotechnology Information; 5 May 2017 (2017-05-05), "Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA", XP055565951, Database accession no. NR-024380.1
GUZZO, R. M. ET AL.: "Establishment of Human cell Type-Specific iPS cells with Enhanced Chondrogenic Potential", STEM CELL REVIEWS AND REPORTS, vol. 10, no. 6, December 2014 (2014-12-01), pages 820 - 829, XP055564627

OKADA, Masahiro (JP)

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