Title:
METHOD OF PREPARING 17beta-(N-TERT-BUTYLCARBAMOYL)-3-ONE STEROID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003027132
Kind Code:
A8
Abstract:
A highly pure 17beta-N-tert-butylcarbamoyl-3-one steroid compound of formula (I) is prepared in a high yield under a mild condition, by reacting a 17beta-carboxy-3-one steroid compound with a pivaloyl halide to obtain a pivaloyl acid anhydride and reacting the pivaloyl acid anhydride with t-butylamine in an organic solvent in the presence of a base formula (I) wherein X is CH2, CH, NH or N; is a single or double bond; and Y is Cl, Br or I.
Inventors:
MOON YOUNGHO (KR)
KIM NAMDU (KR)
LEE KYUNGIK (KR)
KIM CHEOLKYUNG (KR)
LEE GWANSUN (KR)
CHANG YOUNGKIL (KR)
KIM NAMDU (KR)
LEE KYUNGIK (KR)
KIM CHEOLKYUNG (KR)
LEE GWANSUN (KR)
CHANG YOUNGKIL (KR)
Application Number:
PCT/KR2002/001776
Publication Date:
April 29, 2004
Filing Date:
September 19, 2002
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
MOON YOUNGHO (KR)
KIM NAMDU (KR)
LEE KYUNGIK (KR)
KIM CHEOLKYUNG (KR)
LEE GWANSUN (KR)
CHANG YOUNGKIL (KR)
MOON YOUNGHO (KR)
KIM NAMDU (KR)
LEE KYUNGIK (KR)
KIM CHEOLKYUNG (KR)
LEE GWANSUN (KR)
CHANG YOUNGKIL (KR)
International Classes:
C07D215/227; C07J41/00; C07J73/00; (IPC1-7): C07D215/227
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