Title:
METHOD FOR PRODUCING MONOCLONAL IgA ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2014/142084
Kind Code:
A1
Abstract:
Provided are: a component for exhibiting the effect of improving or optimizing the intestinal environment of an organism, or preventing intestinal rot, or preventing abnormal reproduction of intestinal cells and/or preventing pathological changes thereof; an active ingredient which is favorable used in the treatment of intestinal patients; and a monoclonal IgA antibody which bonds to the amino acid in the 1-333 position of serine hydroxymethyltransferase.
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Inventors:
SHINKURA REIKO (JP)
Application Number:
PCT/JP2014/056216
Publication Date:
September 18, 2014
Filing Date:
March 10, 2014
Export Citation:
Assignee:
KANSAI BUNRI SOGO GAKUEN (JP)
International Classes:
C12N15/09; A23L1/305; A61K39/395; A61P1/00; A61P1/04; A61P3/04; A61P11/06; A61P37/06; A61P37/08; C07K16/12
Other References:
REIKO SHINKURA ET AL.: "Chonai Flora Seigyo ni Yuko na Chokan IgA Kotai no Bunri", YAKULT BIO- SCIENCE FOUNDATION NENPO, 31 January 2013 (2013-01-31), pages 50 - 57, XP008182704
MIN WEI ET AL.: "Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense", NATURE IMMUNOLOGY, vol. 12, no. 3, March 2011 (2011-03-01), pages 264 - 270, XP055290921
REIKO SHINKURA: "Chonai Flora Seigyo ni Yuko na Chokan IgA Kotai no Bunri to sono Oyo", YAKULT BIO-SCIENCE FOUNDATION NENPO, 30 September 2013 (2013-09-30), pages 32 - 40, XP008182703
CERF-BENSUSSAN N; GABORIAU-ROUTHIAU V, NAT REV IMMUNOL, vol. 10, 2010, pages 735
HOOPER LV; MACPHERSON AJ, NAT REV IMMUNOL, vol. 10, 2010, pages 159
ROUND JL; MAZMANIAN SK, PROC NATL ACAD SCI USA, vol. 107, 2010, pages 12204
VIJAY-KUMAR M ET AL., SCIENCE, vol. 328, 2010, pages 228
SHULZHENKO N ET AL., NAT MED, vol. 17, 2011, pages 1585
BRY L ET AL., SCIENCE, vol. 273, 1996, pages 1380
TURNBAUGH PJ ET AL., NATURE, vol. 444, 2006, pages 1027
CERUTTI A ET AL., ANN NY ACAD SCI, vol. 1238, 2011, pages 132
FAGARASAN S ET AL., ANNU REV IMMUNOL, vol. 28, 2010, pages 243
FERNANDEZ MI ET AL., IMMUNITY, vol. 18, 2003, pages 739
MARTINOLI C ET AL., IMMUNITY, vol. 27, 2007, pages 975
BOULLIER S ET AL., J IMMUNOL, vol. 183, 2009, pages 5879
PHALIPON A ET AL., IMMUNITY, vol. 17, 2002, pages 107
MACPHERSON AJ; UHR T, SCIENCE, vol. 303, 2004, pages 1662
SHINKURA R ET AL., NAT IMMUNOL, vol. 5, 2004, pages 707
TA VT ET AL., NAT IMMUNOL, vol. 4, 2003, pages 843
CHAUDHURI J ET AL., NATURE, vol. 422, 2003, pages 726
WEI M ET AL., NATURE IMMUNOLOGY, vol. 12, no. 3, 2011, pages 264 - 270
KARLIN S; ALTSCHUL SF, PROC NATL ACAD SCI USA., vol. 87, 1990, pages 2264 - 2268
KARLIN S; ALTSCHUL SF, NATL ACAD SCI USA, vol. 90, 1993, pages 5873 - 7
ALTSCHUL SF; GISH W; MILLER W; MYERS EW; LIPMAN DJ, J MOL BIOL, vol. 215, 1990, pages 403 - 10
LI C ET AL., SHENG WU GONG CHENG XUE BAO., vol. 27, no. 2, February 2011 (2011-02-01), pages 219 - 25
See also references of EP 2995679A4
MIN WEI ET AL.: "Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense", NATURE IMMUNOLOGY, vol. 12, no. 3, March 2011 (2011-03-01), pages 264 - 270, XP055290921
REIKO SHINKURA: "Chonai Flora Seigyo ni Yuko na Chokan IgA Kotai no Bunri to sono Oyo", YAKULT BIO-SCIENCE FOUNDATION NENPO, 30 September 2013 (2013-09-30), pages 32 - 40, XP008182703
CERF-BENSUSSAN N; GABORIAU-ROUTHIAU V, NAT REV IMMUNOL, vol. 10, 2010, pages 735
HOOPER LV; MACPHERSON AJ, NAT REV IMMUNOL, vol. 10, 2010, pages 159
ROUND JL; MAZMANIAN SK, PROC NATL ACAD SCI USA, vol. 107, 2010, pages 12204
VIJAY-KUMAR M ET AL., SCIENCE, vol. 328, 2010, pages 228
SHULZHENKO N ET AL., NAT MED, vol. 17, 2011, pages 1585
BRY L ET AL., SCIENCE, vol. 273, 1996, pages 1380
TURNBAUGH PJ ET AL., NATURE, vol. 444, 2006, pages 1027
CERUTTI A ET AL., ANN NY ACAD SCI, vol. 1238, 2011, pages 132
FAGARASAN S ET AL., ANNU REV IMMUNOL, vol. 28, 2010, pages 243
FERNANDEZ MI ET AL., IMMUNITY, vol. 18, 2003, pages 739
MARTINOLI C ET AL., IMMUNITY, vol. 27, 2007, pages 975
BOULLIER S ET AL., J IMMUNOL, vol. 183, 2009, pages 5879
PHALIPON A ET AL., IMMUNITY, vol. 17, 2002, pages 107
MACPHERSON AJ; UHR T, SCIENCE, vol. 303, 2004, pages 1662
SHINKURA R ET AL., NAT IMMUNOL, vol. 5, 2004, pages 707
TA VT ET AL., NAT IMMUNOL, vol. 4, 2003, pages 843
CHAUDHURI J ET AL., NATURE, vol. 422, 2003, pages 726
WEI M ET AL., NATURE IMMUNOLOGY, vol. 12, no. 3, 2011, pages 264 - 270
KARLIN S; ALTSCHUL SF, PROC NATL ACAD SCI USA., vol. 87, 1990, pages 2264 - 2268
KARLIN S; ALTSCHUL SF, NATL ACAD SCI USA, vol. 90, 1993, pages 5873 - 7
ALTSCHUL SF; GISH W; MILLER W; MYERS EW; LIPMAN DJ, J MOL BIOL, vol. 215, 1990, pages 403 - 10
LI C ET AL., SHENG WU GONG CHENG XUE BAO., vol. 27, no. 2, February 2011 (2011-02-01), pages 219 - 25
See also references of EP 2995679A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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