Title:
METHOD FOR PRODUCTION OF beta-CRYPTOXANTHIN AND alpha-CRYPTOXANTHIN FROM COMMERCIALLY AVAILABLE LUTEIN
Document Type and Number:
WIPO Patent Application WO2003066547
Kind Code:
A3
Abstract:
The present invention relates to a method of reacting (3R,3'R,6'R)-lutein with a catalytic amount of an acid to obtain a mixture of anhydroluteins, rich in anhydrolutein III, with substantially no Z-isomers being formed. The mixture is converted to (3R)-beta-cryptoxanthin (major product) and (3R,6'R)-alpha-cryptoxanthin (minor product) by reacting the anhydroluteins with borane-amine complexes (e.g. Me3N.BH3) or other hydride donors and an acid in a chlorinated solvent, preferably dichloromethane, at ambient temperature to produce (3R)-beta-cryptoxanthin and (3R,6'R)-alpha-cryptoxanthin.
Inventors:
KHACHIK FREDERICK (US)
Application Number:
PCT/US2003/003440
Publication Date:
October 16, 2003
Filing Date:
February 06, 2003
Export Citation:
Assignee:
UNIV MARYLAND (US)
KHACHIK FREDERICK (US)
KHACHIK FREDERICK (US)
International Classes:
C07B61/00; C07C29/60; C07C1/00; C07C29/00; C07C29/17; C07C29/56; C07C29/78; C07C35/21; C07C41/09; C07C43/196; C07C45/28; C07C403/24; C07C; (IPC1-7): C07C29/60; C07C41/09
Domestic Patent References:
| WO2001083414A1 | 2001-11-08 | |||
| WO2002010128A2 | 2002-02-07 |
Foreign References:
| US6420614B1 | 2002-07-16 |
Other References:
See also references of EP 1480932A4
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