Title:
METHOD FOR SCREENING FOR Nrf1 REGULATOR
Document Type and Number:
WIPO Patent Application WO/2013/111909
Kind Code:
A1
Abstract:
The invention provides a method for the screening of compounds that regulate Nrf1 activity from among sample compounds, said method using Nrf1 and Lipin1 and/or PGC-1β. The invention provides a method for the screening of compounds that regulate Nrf1 activity.
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Inventors:
YAMAMOTO MASAYUKI (JP)
FURUSAWA YUKI (JP)
FURUSAWA YUKI (JP)
Application Number:
PCT/JP2013/051941
Publication Date:
August 01, 2013
Filing Date:
January 23, 2013
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68; C12N15/09
Other References:
HIROTSU, Y. ET AL.: "NF-E2-related factor 1 (Nrfl) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipinl and PGC-lp genes.", MOL. CELL. BIOL., vol. 32, no. 14, July 2012 (2012-07-01), pages 2760 - 2770
XU, Z. ET AL.: "Liver-specific inactivation of the Nrfl gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.", PROC. NATL. ACAD. SCI. USA, vol. 102, no. LL, 15 March 2005 (2005-03-15), pages 4120 - 4125
BISWAS, M. ET AL.: "Role of Nrfl in antioxidant response element-mediated gene expression and beyond.", TOXICOL. APPL. PHARMACOL., vol. 244, no. 1, 1 April 2010 (2010-04-01), pages 16 - 20
OHTSUJI, M. ET AL.: "Nrfl and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.", J. BIOL. CHEM., vol. 283, no. 48, 28 November 2008 (2008-11-28), pages 33554 - 33562
MYHRSTAD, M.C.W. ET AL.: "TCFll/Nrfl overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter.", BIOCHIM. BIOPHYS. ACTA, vol. 1517, no. 2, 26 January 2001 (2001-01-26), pages 212 - 219
WU, J.-L. ET AL.: "MCRS2 represses the transactivation activities of Nrfl.", BMC CELL BIOL., vol. 10, no. 9, 2 February 2009 (2009-02-02), pages L-15
XU, Z. ET AL.: "Liver-specific inactivation of the Nrfl gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.", PROC. NATL. ACAD. SCI. USA, vol. 102, no. LL, 15 March 2005 (2005-03-15), pages 4120 - 4125
BISWAS, M. ET AL.: "Role of Nrfl in antioxidant response element-mediated gene expression and beyond.", TOXICOL. APPL. PHARMACOL., vol. 244, no. 1, 1 April 2010 (2010-04-01), pages 16 - 20
OHTSUJI, M. ET AL.: "Nrfl and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.", J. BIOL. CHEM., vol. 283, no. 48, 28 November 2008 (2008-11-28), pages 33554 - 33562
MYHRSTAD, M.C.W. ET AL.: "TCFll/Nrfl overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter.", BIOCHIM. BIOPHYS. ACTA, vol. 1517, no. 2, 26 January 2001 (2001-01-26), pages 212 - 219
WU, J.-L. ET AL.: "MCRS2 represses the transactivation activities of Nrfl.", BMC CELL BIOL., vol. 10, no. 9, 2 February 2009 (2009-02-02), pages L-15
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Hiroshi Kobayashi (JP)
Hiroshi Kobayashi (JP)
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