Title:
METHODS AND COMPOSITIONS FOR SELECTIVE RNAi MEDIATED INHIBITION OF GENE EXPRESSION IN MAMMAL CELLS
Document Type and Number:
WIPO Patent Application WO2004078950
Kind Code:
A3
Abstract:
RNAi arrays and methods for using the same are provided. The subject arrays are characterized by having two or more distinct RNAi agents. The arrays find use in methods where cells are contacted with the arrays and the activity of the RNAi agents is determined by evaluating the contacted cells. The subject arrays and methods find use in a variety of applications, such as high throughput loss of function genomic applications.
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Inventors:
CHI JEN-TSAN (US)
CHANG HOWARD Y (US)
BROWN PATRICK (US)
CHANG HOWARD Y (US)
BROWN PATRICK (US)
Application Number:
PCT/US2004/007053
Publication Date:
March 02, 2006
Filing Date:
March 04, 2004
Export Citation:
Assignee:
UNIV THE BOARD OF TRUSTEES OF (US)
CHI JEN-TSAN (US)
CHANG HOWARD Y (US)
BROWN PATRICK (US)
CHI JEN-TSAN (US)
CHANG HOWARD Y (US)
BROWN PATRICK (US)
International Classes:
A61K48/00; C12N1/00; C12N15/11; C12N15/85; C12Q1/68; C12N; (IPC1-7): A61K48/00; C07H21/00; C12Q1/68
Other References:
YU J. ET AL: "RNA Interference by Expression of Short-Interfering RNAs and Hairpin RNAs in Mammalian Cells", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 9, April 2002 (2002-04-01), pages 6047 - 6052, XP002259803
SUI G. ET AL: "A DNA Vector-Based RNAi Technology to Suppress Gene Expression in Mammalian Cells", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 8, April 2002 (2002-04-01), pages 5515 - 5520, XP002964701
SUI G. ET AL: "A DNA Vector-Based RNAi Technology to Suppress Gene Expression in Mammalian Cells", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 8, April 2002 (2002-04-01), pages 5515 - 5520, XP002964701
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