Title:
MONOCYCLIC $g(b)-LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2000/005204
Kind Code:
A1
Abstract:
Chymase inhibitors and cytokine production inhibitors containing compounds represented by general formula (I), prodrugs of the same, pharmaceutically acceptable salts thereof or hydrates of them, wherein A is -CO-, -CONH- or the like; R?1¿ is optionally substituted lower alkyl, optionally substituted aryl or the like; R?2¿ and R?3¿ are each independently hydrogen, optionally substituted lower alkyl or the like; B is -S-, -O- or the like; and R?4¿ is optionally substituted aryl or the like.
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Inventors:
UENAKA MASAAKI (JP)
KII MAKOTO (JP)
NAKAJIMA MASATOSHI (JP)
KII MAKOTO (JP)
NAKAJIMA MASATOSHI (JP)
Application Number:
PCT/JP1999/003864
Publication Date:
February 03, 2000
Filing Date:
July 16, 1999
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UENAKA MASAAKI (JP)
KII MAKOTO (JP)
NAKAJIMA MASATOSHI (JP)
UENAKA MASAAKI (JP)
KII MAKOTO (JP)
NAKAJIMA MASATOSHI (JP)
International Classes:
C07D205/08; C07D205/09; C07D405/06; C07D405/12; (IPC1-7): C07D205/08; A61K31/395; A61K31/40; A61K31/44; A61K31/445; A61K31/495; A61K31/505; A61K31/535; C07D401/12; C07D403/12; C07D405/06; C07D405/12; C07D405/14
Domestic Patent References:
| WO1996019451A1 | 1996-06-27 | |||
| WO1995002579A1 | 1995-01-26 | |||
| WO1997013750A1 | 1997-04-17 |
Foreign References:
| GB2266527A | 1993-11-03 | |||
| JPH026471A | 1990-01-10 | |||
| JPH08502752A | 1996-03-26 | |||
| JPH06263723A | 1994-09-20 | |||
| JPH07242624A | 1995-09-19 |
Other References:
ADLINGTON R.M. ET AL: "An investigation of the N-arylsulfonylation of 2-azetidinones", SYNTH. COMMUN., vol. 27, no. 21, 1997, pages 3803 - 3813, XP002926607
ADLINGTON R.M. ET AL: "Design and synthesis of novel monocyclic beta lactam inhibitors of prostate specific antigen", BIOORG. MED. CHEM. LETT., vol. 7, no. 13, 1997, pages 1689 - 1694, XP002926608
FINKE P.E. ET AL: "Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones", J. MED. CHEM., vol. 38, no. 13, 1995, pages 2449 - 2462, XP002926609
See also references of EP 1099690A4
ADLINGTON R.M. ET AL: "Design and synthesis of novel monocyclic beta lactam inhibitors of prostate specific antigen", BIOORG. MED. CHEM. LETT., vol. 7, no. 13, 1997, pages 1689 - 1694, XP002926608
FINKE P.E. ET AL: "Orally active beta-lactam inhibitors of human leukocyte elastase. 3. Stereospecific synthesis and structure-activity relationships for 3,3-dialkylazetidin-2-ones", J. MED. CHEM., vol. 38, no. 13, 1995, pages 2449 - 2462, XP002926609
See also references of EP 1099690A4
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Patent Dept. 12-4 Sagisu 5-chome Fukushima-ku, Osaka-shi Osaka, JP)
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