Title:
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2017/084629
Kind Code:
A1
Abstract:
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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Inventors:
CHEN YONGSHENG (CN)
SMITH PETER ANDREW (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
SCHWARZ JACOB BRADLEY (US)
CRAWFORD JAMES JOHN (US)
LY CUONG Q (US)
HU HUIYONG (US)
YU ZHIYONG (CN)
SMITH PETER ANDREW (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
SCHWARZ JACOB BRADLEY (US)
CRAWFORD JAMES JOHN (US)
LY CUONG Q (US)
HU HUIYONG (US)
YU ZHIYONG (CN)
Application Number:
PCT/CN2016/106597
Publication Date:
May 26, 2017
Filing Date:
November 21, 2016
Export Citation:
Assignee:
RQX PHARMACEUTICALS INC (US)
GENENTECH INC (US)
GENENTECH INC (US)
International Classes:
C07D245/04; A61K31/395; A61P31/04
Domestic Patent References:
| WO2014081886A1 | 2014-05-30 | |||
| WO2012166665A2 | 2012-12-06 | |||
| WO2017084630A1 | 2017-05-26 | |||
| WO2015179441A2 | 2015-11-26 | |||
| WO2014081886A1 | 2014-05-30 | |||
| WO2012166665A2 | 2012-12-06 | |||
| WO2013138187A1 | 2013-09-19 | |||
| WO2011112441A1 | 2011-09-15 | |||
| WO2014081886A1 | 2014-05-30 | |||
| WO2012166665A2 | 2012-12-06 | |||
| WO2013138187A1 | 2013-09-19 | |||
| WO2011112441A1 | 2011-09-15 |
Foreign References:
| CN103788176A | 2014-05-14 |
Other References:
GREENE, T.W.WUTS, P. G. M.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"Approved Standard - Eighth Edition. CLSI document M07-A8", 2009, CLINICAL AND LABORATROY STANDARDS, article "Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically"
B MARTINSILHAVY T.: "Imp/OstA is required for cell envelope biogenesis in Escherichia coli", MOLECULAR MICROBIOLOGY, vol. 45, no. 5, 2002, pages 1289 - 1302, XP002337829, DOI: 10.1046/j.1365-2958.2002.03091.x
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"Approved Standard - Eighth Edition. CLSI document M07-A8", 2009, CLINICAL AND LABORATROY STANDARDS, article "Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically"
B MARTINSILHAVY T.: "Imp/OstA is required for cell envelope biogenesis in Escherichia coli", MOLECULAR MICROBIOLOGY, vol. 45, no. 5, 2002, pages 1289 - 1302, XP002337829, DOI: 10.1046/j.1365-2958.2002.03091.x
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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