Title:
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2017/084630
Kind Code:
A1
Abstract:
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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Inventors:
CHEN YONGSHENG (CN)
SMITH PETER ANDREW (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
SCHWARZ JACOB BRADLEY (US)
CRAWFORD JAMES JOHN (US)
LY CUONG Q (US)
HANAN EMILY J (US)
HU HUIYONG (US)
YU ZHIYONG (CN)
SMITH PETER ANDREW (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
SCHWARZ JACOB BRADLEY (US)
CRAWFORD JAMES JOHN (US)
LY CUONG Q (US)
HANAN EMILY J (US)
HU HUIYONG (US)
YU ZHIYONG (CN)
Application Number:
PCT/CN2016/106598
Publication Date:
May 26, 2017
Filing Date:
November 21, 2016
Export Citation:
Assignee:
RQX PHARMACEUTICALS INC (US)
GENENTECH INC (US)
GENENTECH INC (US)
International Classes:
A61K31/395; C07D245/04; A61K38/08; A61P31/04
Domestic Patent References:
WO2014081886A1 | 2014-05-30 | |||
WO2012166665A2 | 2012-12-06 | |||
WO2013138187A1 | 2013-09-19 | |||
WO2013138187A1 | 2013-09-19 |
Foreign References:
CN103788176A | 2014-05-14 |
Other References:
LIU JIAN ET AL: "Efforts toward broadening the spectrum of arylomycin antibiotic activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 20, 14 August 2013 (2013-08-14), pages 5654 - 5659, XP028731070, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2013.08.026
LIU, JIAN ET AL., BIOORG. MED. CHEM. LETT., vol. 23, no. 20, 2013, pages 5654 - 9
GREENE, T.W.WUTS, P. G. M.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Performance Standards for Antimicrobial Susceptibility Testing", 2006, WAYNE, article "Clinical and Laboratory Standards Institute/NCCLS", pages: M100 - S16
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", JOHN WILEY AND SONS
See also references of EP 3377473A4
LIU, JIAN ET AL., BIOORG. MED. CHEM. LETT., vol. 23, no. 20, 2013, pages 5654 - 9
GREENE, T.W.WUTS, P. G. M.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Performance Standards for Antimicrobial Susceptibility Testing", 2006, WAYNE, article "Clinical and Laboratory Standards Institute/NCCLS", pages: M100 - S16
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", JOHN WILEY AND SONS
See also references of EP 3377473A4
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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