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Patent Searching and Data


Title:
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2017/084630
Kind Code:
A1
Abstract:
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Inventors:
CHEN YONGSHENG (CN)
SMITH PETER ANDREW (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
SCHWARZ JACOB BRADLEY (US)
CRAWFORD JAMES JOHN (US)
LY CUONG Q (US)
HANAN EMILY J (US)
HU HUIYONG (US)
YU ZHIYONG (CN)
Application Number:
PCT/CN2016/106598
Publication Date:
May 26, 2017
Filing Date:
November 21, 2016
Export Citation:
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Assignee:
RQX PHARMACEUTICALS INC (US)
GENENTECH INC (US)
International Classes:
A61K31/395; C07D245/04; A61K38/08; A61P31/04
Domestic Patent References:
WO2014081886A12014-05-30
WO2012166665A22012-12-06
WO2013138187A12013-09-19
WO2013138187A12013-09-19
Foreign References:
CN103788176A2014-05-14
Other References:
LIU JIAN ET AL: "Efforts toward broadening the spectrum of arylomycin antibiotic activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 20, 14 August 2013 (2013-08-14), pages 5654 - 5659, XP028731070, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2013.08.026
LIU, JIAN ET AL., BIOORG. MED. CHEM. LETT., vol. 23, no. 20, 2013, pages 5654 - 9
GREENE, T.W.WUTS, P. G. M.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
LIT ET AL.: "Salt Selection for Basic Drugs", INT J. PHARM., vol. 33, 1986, pages 201 - 217
"Design of Prodrugs", 1985, ELSEVIER
"Performance Standards for Antimicrobial Susceptibility Testing", 2006, WAYNE, article "Clinical and Laboratory Standards Institute/NCCLS", pages: M100 - S16
"Fieser and Fieser's Reagents for Organic Synthesis", vol. 1-40, 1991, JOHN WILEY AND SONS
"Larock's Comprehensive Organic Transformations", vol. 1-5, 1989, ELSEVIER SCIENCE PUBLISHERS
"March's Advanced Organic Chemistry", JOHN WILEY AND SONS
See also references of EP 3377473A4
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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