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Patent Searching and Data


Title:
MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2015/050989
Kind Code:
A3
Abstract:
The compounds and salts of the present invention inhibit kinases, especially the anaplastic lymphoma kinase (ALK) and the HGF receptor tyrosine kinase (RTK) c-Met, and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Inventors:
SONG, Yuntao (620 Wellsbury Way, Palo Alto, CA, 94306, US)
BRIDGES, Alexander, James (3389 Surrey Drive, Saline, MI, 48176, US)
Application Number:
US2014/058623
Publication Date:
September 24, 2015
Filing Date:
October 01, 2014
Export Citation:
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Assignee:
CS THERAPEUTICS INC. (620 Wellsbury Way, Palo Alto, CA, 94306, US)
International Classes:
C07D491/18; A61K31/435; A61P35/00; C07D491/22; C07D495/18; C07D495/22; C07D497/18; C07D498/18; C07D498/22; C07D515/18; C07D521/00
Foreign References:
US20130252961A12013-09-26
US20110152310A12011-06-23
Other References:
TED W. JOHNSON ET AL: "Discovery of (10 R )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- 2H -8,4-(metheno)pyrazolo[4,3- h ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 11, 12 June 2014 (2014-06-12), pages 4720 - 4744, XP055136233, ISSN: 0022-2623, DOI: 10.1021/jm500261q
Attorney, Agent or Firm:
NEY, Joshua, E. et al. (Brinks Gilson & Lione, 524 South Main Street Suite 20, Ann Arbor MI, 48104, US)
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