Title:
MACROCYCLIC HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS ANTIMICROBIAL AGENTS
Document Type and Number:
WIPO Patent Application WO2001040198
Kind Code:
A3
Abstract:
The invention concerns macrocyclic hydroxamic acid derivatives of general formula (I) wherein: Y is -CH2-, -CH2-CH2- or -CH=CH- and Z and Z' represent -CH2- or Y-Z or Y-Z' represent -CH=CH- and Z and Z' are defined as above; X is -CH2, O, or S; R1 is non-substituted or substituted phenyl or cycloalkyl (5 to 6 members), monocyclic or bicyclic heterocyclyl (5 to 10 members), saturated or unsaturated (1 to 3 heteroatoms: N, O or S), optionally substituted or N-oxidized, or alkyl optionally substituted; R2 is H, alkyl or hydroxyalkyl optionally substituted; R3 is H, alkyl, alkyloxycarbonyl, carbamoyl, alkylcarbamoyl or dialkylcarbamoyl, or R2 and R3 form with the atoms to which they are bound, a nitrogenous heterocycle with 5 to 6 members capable of further containing another heteroatom selected among N, O or S, and optionally substituted, with an alkyl radical, hydroxyalkyl or OH; R4 and R'4, identical or different, represent H, OH, alkyl, hydroxyalkyl or alkyloxy; the C1-C4 alkyl or acyl radicals are linear or branched; and their salts when they exist and when R4 and R'4 are different, their diastereoisomeric forms. The derivatives of general formula (I) are particularly useful as antimicrobial agents.
Inventors:
CAPET MARC (FR)
GENEVOIS-BORELLA ARIELLE (FR)
MARTIN JEAN-PAUL (FR)
MIKOL VINCENT (FR)
CARREZ CHANTAL (FR)
WENTZLER SYLVIE (FR)
GENEVOIS-BORELLA ARIELLE (FR)
MARTIN JEAN-PAUL (FR)
MIKOL VINCENT (FR)
CARREZ CHANTAL (FR)
WENTZLER SYLVIE (FR)
Application Number:
PCT/FR2000/003333
Publication Date:
November 29, 2001
Filing Date:
November 29, 2000
Export Citation:
Assignee:
AVENTIS PHARMA SA (FR)
CAPET MARC (FR)
GENEVOIS BORELLA ARIELLE (FR)
MARTIN JEAN PAUL (FR)
MIKOL VINCENT (FR)
CARREZ CHANTAL (FR)
WENTZLER SYLVIE (FR)
CAPET MARC (FR)
GENEVOIS BORELLA ARIELLE (FR)
MARTIN JEAN PAUL (FR)
MIKOL VINCENT (FR)
CARREZ CHANTAL (FR)
WENTZLER SYLVIE (FR)
International Classes:
A61P31/04; C07D245/02; C07D401/06; C07D403/06; (IPC1-7): C07D245/02; A61K31/395; A61P31/04; C07D401/06; C07D403/06
Domestic Patent References:
WO1999059568A1 | 1999-11-25 |
Foreign References:
US4692510A | 1987-09-08 |
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