Title:
MACROCYCLIC KINASE INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/016186
Kind Code:
A8
Abstract:
The present invention provides macrocyclic compounds of Formula (I): pharmaceutically acceptable salts thereof; and pharmaceutical compositions thereof, wherein R1, R2, R3, R4, RE, RF, RG, RH, RI, f, g, h, n, and m are as defined herein. The present invention further provides methods of synthesizing these macrocyclic compounds, and methods of their use and treatment. Certain aspects of the present invention relate to modulation of kinase activity, and in the treatment of kinase-associated diseases or disorders.
Inventors:
LIU DAVID R (US)
KLEINER RALPH E (US)
KLEINER RALPH E (US)
Application Number:
PCT/US2011/045966
Publication Date:
February 07, 2013
Filing Date:
July 29, 2011
Export Citation:
Assignee:
HARVARD COLLEGE (US)
LIU DAVID R (US)
KLEINER RALPH E (US)
LIU DAVID R (US)
KLEINER RALPH E (US)
International Classes:
A61K38/12; A61K38/06; A61K38/08
Attorney, Agent or Firm:
BAKER, C., Hunter (Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, US)
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