Title:
MACROCYCLIC LACTAM-BASED DERIVATIVE COMPOUND, PRODUCTION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/110799
Kind Code:
A1
Abstract:
Provided are a compound represented by any one of chemical formulas 1 to 3, or an isomer, derivative, solvate, or pharmaceutically acceptable salt thereof, a production method therefor, and a use thereof. According to this, antibacterial activity and antibacterial activity against antibiotic-resistant bacteria are used to suppress the growth of bacteria and antibiotic-resistant bacteria, and can be used in the prevention or treatment of an inflammatory disease induced by bacteria or caused by bacteria, for example, bacillary paralysis of silkworms.
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Inventors:
OH DONG-CHAN (KR)
SHIN JONGHEON (KR)
OH KI-BONG (KR)
SHIN YERN-HYERK (KR)
SHIN JONGHEON (KR)
OH KI-BONG (KR)
SHIN YERN-HYERK (KR)
Application Number:
PCT/KR2017/009750
Publication Date:
June 21, 2018
Filing Date:
September 06, 2017
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07D225/02; A23K20/132; A61K31/395; C12N1/20; C12P17/10; C12P17/18; C12R1/465
Other References:
SCHULZ, D. ET AL.: "Piceamycin and Its N-acetylcysteine Adduct Is Produced by Streptomyces sp. GB 4-2", THE JOURNAL OF ANTIBIOTICS, vol. 62, no. 9, 17 July 2009 (2009-07-17), pages 513 - 518, XP055510493
OH, D.-C. ET AL.: "Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp- associated Streptomyces sp.", ORGANIC LETTERS, vol. 13, no. 4, 2011, pages 752 - 755, XP055510496
POULSEN, M. ET AL.: "Chemical Analyses of Wasp-associated Streptomyces Bacteria Reveal a Prolific Potential for Natural Products Discovery", PLOS ONE, vol. 6, no. 2, February 2011 (2011-02-01), pages 1 - 8, XP055510498
SCHULZ, D. ET AL.: "Silvalactam, a 24-membered Macrolactam Antibiotic Produced by Streptomyces sp. Tu 6392", THE JOURNAL OF ANTIBIOTICS, vol. 65, 2012, pages 369 - 372, XP055510501
TAKAISHI, M. ET AL.: "A Unique Pathway for the 3-aminobutyrate Starter Unit from L-glutamate through beta-glutamate during Biosynthesis of the 24-membered Macrolactam Antibiotic, Incednine", ORGANIC LETTERS, vol. 14, no. 17, 2012, pages 4591 - 4593, XP055510504
SHIN, Y.-H. ET AL.: "Discovery of New Macrocyclic Lactams from an Intestinal Bacterial Strain of the Silkworm Bombyx mori", KMB 2016 43RD ANNUAL MEETING & INTERNATIONAL SYMPOSIUM, 22 June 2016 (2016-06-22)
OH, D.-C. ET AL.: "Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp- associated Streptomyces sp.", ORGANIC LETTERS, vol. 13, no. 4, 2011, pages 752 - 755, XP055510496
POULSEN, M. ET AL.: "Chemical Analyses of Wasp-associated Streptomyces Bacteria Reveal a Prolific Potential for Natural Products Discovery", PLOS ONE, vol. 6, no. 2, February 2011 (2011-02-01), pages 1 - 8, XP055510498
SCHULZ, D. ET AL.: "Silvalactam, a 24-membered Macrolactam Antibiotic Produced by Streptomyces sp. Tu 6392", THE JOURNAL OF ANTIBIOTICS, vol. 65, 2012, pages 369 - 372, XP055510501
TAKAISHI, M. ET AL.: "A Unique Pathway for the 3-aminobutyrate Starter Unit from L-glutamate through beta-glutamate during Biosynthesis of the 24-membered Macrolactam Antibiotic, Incednine", ORGANIC LETTERS, vol. 14, no. 17, 2012, pages 4591 - 4593, XP055510504
SHIN, Y.-H. ET AL.: "Discovery of New Macrocyclic Lactams from an Intestinal Bacterial Strain of the Silkworm Bombyx mori", KMB 2016 43RD ANNUAL MEETING & INTERNATIONAL SYMPOSIUM, 22 June 2016 (2016-06-22)
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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