Title:
MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO2008033956
Kind Code:
A9
Abstract:
The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2, (II) -O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o- CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: (III) each of L and L3 are independently selected from the group consisting of: (IV) salts, hydrates, isomers, metabolites and prodrugs thereof.
Inventors:
YAN JOHN (US)
ZHENG XIAOXIA (US)
BHAT VINAYAK D (US)
ZHENG XIAOXIA (US)
BHAT VINAYAK D (US)
Application Number:
PCT/US2007/078317
Publication Date:
September 18, 2008
Filing Date:
September 12, 2007
Export Citation:
Assignee:
ELIXIR MEDICAL CORP (US)
YAN JOHN (US)
ZHENG XIAOXIA (US)
BHAT VINAYAK D (US)
YAN JOHN (US)
ZHENG XIAOXIA (US)
BHAT VINAYAK D (US)
International Classes:
A61K31/787
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