MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

WIPO Patent Application WO/2019/035914

A8

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

WO/1998/000422

OXIRANE CARBOXYLIC ACID DERIVATIVE AND ITS MANUFACTURING METHOD

BRADY PATRICK (US)
BRAJE WILFRIED (DE)
DAI YUJIA (US)
DOHERTY GEORGE (US)
GONG JANE (US)
JANTOS KATJA (DE)
JI CHENG (US)
JUDD ANDREW (US)
KUNZER AARON (US)
MASTRACCHIO ANTHONY (US)
RISI ROBERTO (US)
SONG XIAOHONG (US)
SOUERS ANDREW (US)
SULLIVAN GERARD (US)
TAO ZHI-FU (US)
TESKE JESSE (US)
WANG XILU (US)
WENDT MICHAEL (US)
YU YIYUN (US)
ZHU GUIDONG (US)
PENNING THOMAS (US)
LAI CHUNQUI (US)
KLING ANDREAS (DE)
POHLKI FRAUKE (DE)
POTIN DOMINIQUE (FR)
GUILLIER FABRICE (FR)

PCT/US2018/000183

September 19, 2019

August 15, 2018

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ABBVIE INC (US)
ABBVIE DEUTSCHLAND (DE)
BRADY PATRICK (US)
BRAJE WILFRIED (DE)
DAI YUJIA (US)
DOHERTY GEORGE (US)
GONG JANE (US)
JANTOS KATJA (DE)
JI CHENG (US)
JUDD ANDREW (US)
KUNZER AARON (US)
MASTRACCHIO ANTHONY (US)
RISI ROBERTO (US)
SONG XIAOHONG (US)
SOUERS ANDREW (US)
SULLIVAN GERARD (US)
TAO ZHI FU (US)
TESKE JESSE (US)
WANG XILU (US)
WENDT MICHAEL (US)
YU YIYUN (US)
ZHU GUIDONG (US)
PENNING THOMAS (US)
LAI CHUNQUI (US)
KLING ANDREAS (DE)
POHLKI FRAUKE (DE)
POTIN DOMINIQUE (FR)
GUILLIER FABRICE (FR)

A61K31/395; A61P35/00; C07D515/22

JOHANNES, Laura, E. (US)

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