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Patent Searching and Data


Title:
MACROCYCLIC MODULATORS OF DISEASE ASSOCIATED PROTEIN MISFOLDING AND AGGREGATION
Document Type and Number:
WIPO Patent Application WO/2018/215831
Kind Code:
A3
Abstract:
Aspects of the present invention disclose compounds that modulate the aggregation of amyloidogenic proteins or peptides. In some aspects, disclosed compounds modulate the aggregation of disease-associated proteins and natural β-amyloid peptides. In a preferred embodiment, the compounds can inhibit natural amyloid aggregation. Pharmaceutical compositions comprising the compounds of the embodiments, and diagnostic and treatment methods for diseases (e.g., amyloidogenic diseases) using the compounds, are also disclosed. In addition, there is provided an integrated bacterial platform for the discovery of rescuers of disease-associated protein misfolding.

Inventors:
SKRETAS, Georgios (48 Vassileos Constantinou Avenue, Athens, GR-11635, GR)
Application Number:
IB2018/000622
Publication Date:
February 28, 2019
Filing Date:
May 22, 2018
Export Citation:
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Assignee:
NATIONAL HELLENIC RESEARCH FOUNDATION (48 Vassileos Constantinou Avenue, GR- Athens, GR- Athens, GR- 11635, GR)
International Classes:
A61K38/07; A61K38/08; A61K38/12; C07K5/103; C07K5/12; C07K7/64
Foreign References:
EP2054515A22009-05-06
Other References:
MICHAEL BAINE ET AL: "Inhibition of A[beta]42 aggregation using peptides selected from combinatorial libraries", JOURNAL OF PEPTIDE SCIENCE., vol. 15, no. 8, 1 August 2009 (2009-08-01), GB, pages 499 - 503, XP055522281, ISSN: 1075-2617, DOI: 10.1002/psc.1150
CHENG LIN ET AL: "Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease", PROTEIN SCIENCE, WILEY, US, vol. 16, no. 8, 1 August 2007 (2007-08-01), pages 1535 - 1542, XP002492158, ISSN: 0961-8368, DOI: 10.1110/PS.072933007
TAVASSOLI ALI ED - TAWFIK DAN S ET AL: "SICLOPPS cyclic peptide libraries in drug discovery", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 38, 1 March 2017 (2017-03-01), pages 30 - 35, XP085070173, ISSN: 1367-5931, DOI: 10.1016/J.CBPA.2017.02.016
WOOJIN KIM ET AL: "A High-Throughput Screen for Compounds That Inhibit Aggregation of the Alzheimer's Peptide", ACS CHEMICAL BIOLOGY, vol. 1, no. 7, 4 August 2006 (2006-08-04), pages 461 - 469, XP055522423, ISSN: 1554-8929, DOI: 10.1021/cb600135w
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