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Title:
MACROMOLECULAR TRANSITION METAL COMPLEXES FOR TREATMENT OF CANCER AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/2016/087932
Kind Code:
A3
Abstract:
The present invention relates to macromolecular transition metal complexes, characterized by having the general formula (I), to the process for their preparation, and to bidentate and monodentate macroligands. The invention also refers to pharmaceutical compositions and medicaments containing said macromolecular transition metal complexes, and to the use of said pharmaceutical compositions, medicaments and macromolecular transition metal complexes for cancer therapy and/or cancer prevention, as antitumor agent in solid tumors, liquid tumors and/or metastases and/or as radiosensitizer agents.

Inventors:
ANSELMO VIEGAS GARCIA, Maria Helena (R. Prof. Luís Reis Santos, 5 2º D, 1600-640 Lisboa, PT)
MARQUES VALENTE, Andreia (Rua da Nestlé, n°79, 3860-071 Avanca, PT)
FERREIRA MORAIS, Tânia Sofia (Rua de Baixo 14, 2655-237 Ericeira, PT)
ANTUNES TOMAZ DINIZ, Ana Isabel (Av. D. António Correia da Sá, Nº 2-4º Dto, 2745-241 Queluz, PT)
Application Number:
IB2015/002312
Publication Date:
August 18, 2016
Filing Date:
December 07, 2015
Export Citation:
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Assignee:
FACULDADE DE CIÉNCIAS DA UNIVERSIDADE DE LISBOA (Campo Grande, Edifício C5, 1749-016 Lisboa, PT)
International Classes:
C07F9/50; A61K31/295; A61P35/00; C07D213/22; C07F15/00; C07F15/02; C08G63/08
Other References:
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KAI CAO ET AL: "Organometallic macromolecules with piano stool coordination repeating units: chain configuration and stimulated solution behaviour", CHEMICAL COMMUNICATIONS - CHEMCOM, vol. 50, no. 70, 10 July 2014 (2014-07-10), GB, pages 10062, XP055261330, ISSN: 1359-7345, DOI: 10.1039/C4CC03064H
YI-HSIEN LIAO ET AL: "Ruthenium-containing organometallic dendrimers", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS., no. 23, 1 January 1993 (1993-01-01), GB, pages 1774, XP055261332, ISSN: 0022-4936, DOI: 10.1039/c39930001774
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ELKE DAVID ET AL: "Photoinduced Electron Transfer in Supramolecular Assemblies Composed of One-Shell and Two-Shell Dialkoxybenzene-Tethered Ru(II)-Tris(bipyridine) Derivatives and a Bipyridinium Cyclophane", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 119, no. 33, 1 August 1997 (1997-08-01), US, pages 7778 - 7790, XP055282105, ISSN: 0002-7863, DOI: 10.1021/ja9703382
NING LIU ET AL: "Green synthesis of fluorinated biaryl derivatives via thermoregulated ligand/palladium-catalyzed Suzuki reaction", JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER-SEQUOIA S.A. LAUSANNE, CH, vol. 696, no. 13, 8 April 2011 (2011-04-08), pages 2641 - 2647, XP028222014, ISSN: 0022-328X, [retrieved on 20110415], DOI: 10.1016/J.JORGANCHEM.2011.04.007
CÔRTE-REAL LEONOR ET AL: "The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 150, 20 June 2015 (2015-06-20), pages 148 - 159, XP029322862, ISSN: 0162-0134, DOI: 10.1016/J.JINORGBIO.2015.06.015
Attorney, Agent or Firm:
GARCIA, Teresa (Soldados da India 72, 1400-340 Lisboa, PT)
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