Title:
MACROPHAGE-BASED LIVING CELL DRUG-LOADING SYSTEM, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104058
Kind Code:
A1
Abstract:
The present invention provides a macrophage-based living cell drug-loading system, comprising living cells and drug-loading yeast bionic micro-motors located inside the living cells, wherein the living cells are macrophages, and each drug-loading yeast bionic micro-motor comprises a yeast cell wall, drug-loaded nanoparticles located inside the yeast cell wall, and glucose oxidase and catalase half-surface modified on the yeast cell wall. In vivo self-assembled living cell drugs refer to that the drug-loaded yeast bionic micro-motors actively penetrate the intestinal wall after entering a human body, enter the lymphatic system in the intestine and are endocytosed by the macrophages therein, so that the drug-loaded yeast bionic micro-motors and the macrophages are self-assembled in vivo into macrophage living cell drugs, thereby achieving targeting transport of drugs.
Inventors:
CAI LINTAO (CN)
ZHANG BAOZHEN (CN)
ZHENG MINGBIN (CN)
PAN HONG (CN)
TANG XIAOFAN (CN)
ZHANG BAOZHEN (CN)
ZHENG MINGBIN (CN)
PAN HONG (CN)
TANG XIAOFAN (CN)
Application Number:
PCT/CN2022/137029
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
A61K9/50; A61K45/00; A61K47/46; A61K47/69; A61P1/00; A61P1/04; A61P1/16; A61P3/04; A61P3/10; A61P9/10; A61P19/02; A61P19/08; A61P19/10; A61P25/28; A61P31/14; A61P31/20; A61P35/00
Domestic Patent References:
| WO2020115124A1 | 2020-06-11 |
Foreign References:
| CN114425043A | 2022-05-03 | |||
| CN114425088A | 2022-05-03 | |||
| CN114425089A | 2022-05-03 | |||
| CN105168180A | 2015-12-23 | |||
| CN103120795A | 2013-05-29 |
Other References:
ZHANG MAOJIE, ZHANG PING, ZHAO RUIBIN, YANG YALAN, WANG WEI, CHU LIANGYIN: "Recent progress on controllable fabrication of bubble-propelled functional micromotors", ZHONGGUO KEXUE. HUAXUE - SCIENTIA SINICA CHIMICA, ZHONGGUO KEXUE ZAZHISHE, CN, vol. 49, no. 6, 1 June 2019 (2019-06-01), CN , pages 861 - 876, XP093069324, ISSN: 1674-7224, DOI: 10.1360/N032018-00206
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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