MACROPHAGE FOAMING INHIBITOR FKI-1840 AND PROCESS FOR PRODUCING THE SAME

WIPO Patent Application WO/2006/048947

A1

Macrophage foaming inhibitor FKI-1840, and a process for producing the same, comprising incubating a microbe belonging to the genus Phoma which is capable of producing the substance FKI-1840 (Phoma sp. FKI-1840, FERM ABP-10150) in a culture medium, accumulating the substance FKI-1840 in the culture and collecting the substance FKI-1840 from the culture. The thus obtained substance FKI-1840 has the activity of inhibiting macrophage foaming, so that the use thereof as a preventive or therapeutic drug for atherosclerosis or diseases caused thereby, myocardial infarction, cerebral apoplexy and cerebral stroke is promising.

OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
MASUMA ROKURO (JP)

PCT/JP2004/016615

May 11, 2006

November 02, 2004

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KITASATO INST (JP)
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
MASUMA ROKURO (JP)

A61K31/403; A61P43/00; A61P9/10; C07D209/96; C12N1/14; C12P17/10; (IPC1-7): C07D209/96; A61K31/403; A61P9/10; A61P43/00; C12N1/14; C12P17/10

JPH11279195A	1999-10-12
JP2002275194A	2002-09-25

TONOMURA Y. ET AL.: "Kujiratake Shijittai Yurai no Macrophage Homatsuka Sogai Busshitsu", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY 2003 NENDO (HEISEI 15 NENDO) TAIKAI KOEN YOSHISHU, 2003, pages 270, 3E02P15, XP003006171
NAMATAME K. ET AL.: "Shijokin no Seisan suru Macrophage Homatsuka Sogaizai Beauveriolide-rui ni Kansuru Kenkyu", DAI 44 KAI SYMPOSIUM ON THE CHEMISTRY OF NATURAL PRODUTS, SYMPOSIUM PAPERS, HEISEI 14 NEN 9 GATSU 1 NICHI, pages 181 - 186, XP003006172

Kobayashi, Kazunori (25-1 Kitaotsuka 2-chom, Toshima-ku Tokyo, JP)

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