Title:
MAGNESIUM BASED BIORESORBABLE ELECTRODES FOR RECORDING, STIMULATION AND DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2019/152415
Kind Code:
A3
Abstract:
A bioresorbable electrode including a magnesium microwire and a conductive polymer coating deposited on the Mg microwire; methods of manufacturing the electrode, methods of recording an electrical signal from a neuron with the electrode; methods of electrically stimulating a neuron with the electrode by applying an electrical stimulus to the neuron; and a method for delivering a drug, wherein the conductive polymer is loaded with the drug, and actuating the conductive polymer by applying an electrical stimulation to cause the conductive polymer to change a redox state of the polymer, wherein the drug is released from the conductive polymer.
Inventors:
LIU HUINAN (US)
Application Number:
PCT/US2019/015668
Publication Date:
September 06, 2019
Filing Date:
January 29, 2019
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
H01L29/06; H01L21/02; H01L29/20
Foreign References:
| US9508491B2 | 2016-11-29 | |||
| US20170020402A1 | 2017-01-26 | |||
| US20090012446A1 | 2009-01-08 | |||
| US20160294028A1 | 2016-10-06 |
Other References:
HARRIS, ALEXANDER R ET AL.: "Conducting Polymer Coated Neural Recording Electrodes", JOURNAL OF NEURAL ENGINEERING, vol. 10, no. 1, 12 December 2012 (2012-12-12), XP020238278, doi:10.1088/1741-2560/10/1/016004
MIN JI KIM ET AL.: "Biodegradable and Elastomeric Poly(glycerol sebacate) as a Coating Material for Nitinol Bare Stent", BIOMED RESEARCH INTERNATIONAL, vol. 2014
LORRAINE F. FRANCIS ET AL.: "Chapter 6 - Dispersion and Solution Processes", MATERIALS PROCESSING: A UNIFIED APPROACH TO PROCESSING OF METALS, CERAMICS AND POLYMERS
FATTAHI, POURIA ET AL.: "A review of organic and inorganic biomaterials for neural interfaces", ADVANCED MATERIALS (DEERFIELD BEACH, FLA., vol. 26, no. 12, 2014, pages 1846 - 85, XP055551451, doi:10.1002/adma.201304496
MIN JI KIM ET AL.: "Biodegradable and Elastomeric Poly(glycerol sebacate) as a Coating Material for Nitinol Bare Stent", BIOMED RESEARCH INTERNATIONAL, vol. 2014
LORRAINE F. FRANCIS ET AL.: "Chapter 6 - Dispersion and Solution Processes", MATERIALS PROCESSING: A UNIFIED APPROACH TO PROCESSING OF METALS, CERAMICS AND POLYMERS
FATTAHI, POURIA ET AL.: "A review of organic and inorganic biomaterials for neural interfaces", ADVANCED MATERIALS (DEERFIELD BEACH, FLA., vol. 26, no. 12, 2014, pages 1846 - 85, XP055551451, doi:10.1002/adma.201304496
Attorney, Agent or Firm:
CHRISTENSEN, Michael, R. (US)
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