Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
A MAGNETIC HYBRID HYDROGEL
Document Type and Number:
WIPO Patent Application WO/2012/042467
Kind Code:
A3
Abstract:
The present invention relates to a magnetic hybrid hydrogel comprising a biocompatible, bioreabsorbable polymer crosslinked with magnetic particles which act as crosslinking agents. The polymer can be a polysaccharide chosen from among carboxymethyl cellulose, hyaluronic acid, chitin, alginic acid, alginates, chitosan or combinations thereof; or else a synthetic polymer chosen from among polyacrylic acid, polylactic acid, polyvinylamine or combinations thereof. The magnetic nanoparticles can be nanoparticles of Fe2C>3, Fe304, Fe204 or else mixed nanoparticles of Fe and Co, Mn or Zn, preferably functionalized with -NH2, - COOH,-OH,-SH groups. The hydrogel is used in oncological medicine for the targeted administration and controlled release of a drug, or else in regenerative medicine for applications of cells or other factors for the purpose of regenerating or repairing a tissue or organ.

Inventors:
BARBUCCI ROLANDO (IT)
GIARDINO ROBERTO (IT)
Application Number:
PCT/IB2011/054240
Publication Date:
July 12, 2012
Filing Date:
September 27, 2011
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
BARBUCCI ROLANDO (IT)
ISTITUTO ORTOPEDICO RIZZOLI (IT)
GIARDINO ROBERTO (IT)
International Classes:
C08J3/075; A61K9/00; A61K9/06; C08B15/00; C08B37/00; C08F20/00; C08F26/00; C08G63/00; C08J3/24; C08K3/00
Other References:
FUHRER ROLAND ET AL: "Crosslinking metal nanoparticles into the polymer backbone of hydrogels enables preparation of soft, magnetic field-driven actuators with muscle-like flexibility", SMALL, WILEY - VCH VERLAG GMBH & CO. KGAA, DE, vol. 5, no. 3, 1 March 2009 (2009-03-01), pages 383 - 388, XP009145959, ISSN: 1613-6810
DANIEL-DA-SILVA ANA L ET AL: "Biofunctionalized magnetic hydrogel nanospheres of magnetite and kappa-carrageenan.", NANOTECHNOLOGY 2 SEP 2009 LNKD- PUBMED:19671980, vol. 20, no. 35, 2 September 2009 (2009-09-02), pages 355602, XP020164712, ISSN: 1361-6528
MEENACH SAMANTHA A ET AL: "Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility, and Toxicity Analysis", SAFETY OF NANOPARTICLES: FROM MANUFACTURING TO MEDICAL APPLICATIONS SPRINGER, 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SERIES : NANOSTRUCTURE SCIENCE AND TECHNOLOGY, 2009, pages 131 - 157, XP009145993
LAPOINTE J ET AL: "Thermoresponsive hydrogel with embedded magnetic nanoparticles for the implementation of shrinkable medical microrobots and for targeting and drug delivery applications", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, 2009. EMBC 2009. ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, IEEE, PISCATAWAY, NJ, USA, 3 September 2009 (2009-09-03), pages 4246 - 4249, XP031638186, ISBN: 978-1-4244-3296-7
BARAKAT NAHLA S: "Magnetically modulated nanosystems: a unique drug-delivery platform", NANOMEDICINE,, vol. 4, no. 7, 1 October 2009 (2009-10-01), pages 799 - 812, XP009145958
GUPTA A K ET AL: "Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 18, 1 January 2005 (2005-01-01), pages 3995 - 4021, XP002542497, ISSN: 0142-9612, [retrieved on 20041210], DOI: DOI:10.1016/J.BIOMATERIALS.2004.10.012
Attorney, Agent or Firm:
BIGGI, Cristina (Viale Lancetti 17, Milano, IT)
Download PDF: