Title:
MAGNETIC IRON OXIDE MICROPARTICLE POWDER, AQUEOUS DISPERSION CONTAINING MAGNETIC PARTICLES, AND PROCESS FOR PRODUCTION OF SAME
Document Type and Number:
WIPO Patent Application WO/2011/062217
Kind Code:
A1
Abstract:
Disclosed is a magnetic-particle-containing aqueous dispersion which has an average primary particle diameter of 5 to 15 nm, an average secondary particle diameter of 10 to 60 nm, and has a zeta potential of -20 mV or less at a pH falling within the range from pH6 to 8, wherein the surfaces of the magnetic powder are coated with a polymer having a carboxyl group. The magnetic-particle-containing aqueous dispersion can be produced by heating an aqueous solution having, dissolved therein, a polymer having a carboxyl group to a temperature falling within the range from 90 to 100˚C in a nitrogen atmosphere, adding a solution containing a bivalent iron salt and a trivalent iron salt and an alkaline solution to the heated aqueous solution, causing the resulting mixture to react at that temperature, adding ethanol to the reaction solution to cause precipitation, removing a supernatant from the ethanol-precipitated solution, dissolving the resulting solution in water, and subjecting the resulting solution to dialysis. The magnetic-particle-containing aqueous dispersion is useful for the production of a magnetic-particle-containing medicinal agent for diagnostic purposes, therapeutic purposes or the like which can exhibit a homogeneous function with high reproducibility.
Inventors:
HAKATA TOSHIYUKI (JP)
OKITA TOMOKO (JP)
OKITA TOMOKO (JP)
Application Number:
PCT/JP2010/070555
Publication Date:
May 26, 2011
Filing Date:
November 18, 2010
Export Citation:
Assignee:
TODA KOGYO CORP (JP)
HAKATA TOSHIYUKI (JP)
OKITA TOMOKO (JP)
HAKATA TOSHIYUKI (JP)
OKITA TOMOKO (JP)
International Classes:
A61K9/10; C01G49/02; A61K47/02; A61K49/00; A61K49/04; C01G49/00; C01G49/06; C01G49/08
Domestic Patent References:
| WO2003066644A1 | 2003-08-14 | |||
| WO1995031220A1 | 1995-11-23 |
Foreign References:
| JP2008111703A | 2008-05-15 | |||
| JPS6449206A | 1989-02-23 | |||
| JP2007023027A | 2007-02-01 | |||
| JPH03128331A | 1991-05-31 | |||
| JPH0452202A | 1992-02-20 | |||
| JPH07122410A | 1995-05-12 | |||
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| JPH11106391A | 1999-04-20 | |||
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Other References:
LIN CHIA-LUNG ET AL.: "Preparation and properties of poly(acrylic acid) oligomer stabilized superparamagnetic ferrofluid", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 291, 2005, pages 411 - 420, XP008156168
Attorney, Agent or Firm:
OKADA, KAZUHIKO (JP)
Kazuhiko Okada (JP)
Kazuhiko Okada (JP)
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