Title:
MAIN-GROUP METAL-BASED ASYMMETRIC CATALYSTS AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO1999056699
Kind Code:
A3
Abstract:
The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive pi -bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
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| WO/2000/021663 | POLYMER-SUPPORTED PHOSPHORUS LIGANDS FOR CATALYSIS |
| WO/1988/007033 | PROCESS FOR SELECTIVELY HYDROFORMYLATING DIOLEFIN |
Inventors:
JACOBSEN ERIC N
SIGMAN MATTHEW S
SIGMAN MATTHEW S
Application Number:
PCT/US1999/009570
Publication Date:
May 18, 2000
Filing Date:
April 30, 1999
Export Citation:
Assignee:
HARVARD COLLEGE (US)
International Classes:
B01J31/16; B01J31/18; C07B53/00; C07B57/00; C07C227/12; B01J31/22; C07C227/32; C07C229/36; C07C247/00; C07C251/24; C07C253/08; C07C253/10; C07C255/42; C07C381/00; C07C255/29; C07C255/31; C07C255/44; (IPC1-7): C07B53/00; B01J31/22; C07C253/08; C07B57/00; C07C251/24
Domestic Patent References:
| WO1999051546A1 | 1999-10-14 |
Foreign References:
| EP0641762A1 | 1995-03-08 |
Other References:
M. S. IYER: "Asymmetric catalysis of the Strecker amino acid synthesis by a cyclic dipeptide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, no. 20, 22 May 1996 (1996-05-22), DC US, pages 4910 - 4911, XP002132674
D. A. ATWOOD: "A new class of aluminum cations based upon tetradentate (N2O2) chelating ligands", INORGANIC CHEMISTRY, vol. 35, 1996, EASTON US, pages 63 - 70, XP000874238
M. S. SIGMAN: "Enantioselective addition of hydrogen cyanide to imines catalyzed by a chiral (salen)Al(III) complex", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 21, 3 June 1998 (1998-06-03), DC US, pages 5315 - 5316, XP002132676
D. A. ATWOOD: "A new class of aluminum cations based upon tetradentate (N2O2) chelating ligands", INORGANIC CHEMISTRY, vol. 35, 1996, EASTON US, pages 63 - 70, XP000874238
M. S. SIGMAN: "Enantioselective addition of hydrogen cyanide to imines catalyzed by a chiral (salen)Al(III) complex", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 21, 3 June 1998 (1998-06-03), DC US, pages 5315 - 5316, XP002132676
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