MALE FUNCTION-IMPROVING EFFECT OF HELIPYRONE A

WIPO Patent Application WO/2015/012194

A1

The present invention addresses the problem of newly finding a compound that has no effect other than an effect of increasing cavernous pressure, different from conventional medicinal compositions for treating or ameliorating erectile dysfunction. The present inventors examined various substances derived from natural products with respect to the presence or absence of a male function-improving effect. As a result, they found that the administration of helipyrone A (3,3'-methylenebis(6-ethyl-4-hydroxy-5-methyl-2H-pyran-2-one)), which is a component derived from curry plant belonging to the genus Helichrysum of the family Asteraceae, enhances an cavernous nerve stimulation-induced cavernous pressure increasing effect in the corpus cavernosum of the penis, and thus completed the present invention.

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ORITO KENSUKE (JP)
KOSUGE NAOYA (JP)

PCT/JP2014/069040

January 29, 2015

July 17, 2014

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SCHOOL CORP AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION (JP)

A61K31/366; A61K36/00; A61K36/28; A61P15/10

WO2007125832A1

2007-11-08

JP2013107829A	2013-06-06
JP2014047160A	2014-03-17
JP2014047154A	2014-03-17

ORAZIO TAGLIALATELA-SCAFATI ET AL.: "Antimicrobial Phenolics and Unusual Glycerides from Helichrysum italicum subsp. microphyllum", J NAT PROD., vol. 76, no. 3, March 2013 (2013-03-01), pages 346 - 353

OKUHARA Koji (JP)
Yasushi Okuhara (JP)

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