Title:
MALEIMIDE GROUP-MODIFIED BEAD COMPLEX AND THIOL GROUP-MODIFIED NUCLEOTIDE MOLECULE FOR DETECTING NUCLEIC ACID MOLECULE IN BIOLOGICAL SAMPLE AND METHOD FOR DETECTING NUCLEIC ACID BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2024/063202
Kind Code:
A1
Abstract:
The present invention relates to a method for detecting one or more target nucleic acid molecules in a biological sample. By using the method for detecting one or more target nucleic acid molecules in a biological sample, according to an aspect, a plurality of target nucleic acids can be effectively separated, extracted, and detected in the biological sample. In addition, the presence or absence of a target nucleic acid molecule in the biological sample is analyzed, and thus, there is the effect of improving analytical sensitivity.
Inventors:
JEONG YO HAN (KR)
LEE JEONG JU (KR)
PARK SO HYEON (KR)
LEE JEONG JU (KR)
PARK SO HYEON (KR)
Application Number:
PCT/KR2022/018079
Publication Date:
March 28, 2024
Filing Date:
November 16, 2022
Export Citation:
Assignee:
SML GENETREE CO LTD (KR)
International Classes:
C12Q1/6834; C12Q1/6848; C12Q1/6883; C12Q1/6886
Foreign References:
| US20060002890A1 | 2006-01-05 | |||
| KR102453872B1 | 2022-10-14 |
Other References:
ZHANG HAO, HARPSTER MARK H., PARK HEE JOON, JOHNSON PATRICK A., WILSON WILLIAM C.: "Surface-Enhanced Raman Scattering Detection of DNA Derived from the West Nile Virus Genome Using Magnetic Capture of Raman-Active Gold Nanoparticles", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 83, no. 1, 1 January 2011 (2011-01-01), US , pages 254 - 260, XP093148725, ISSN: 0003-2700, DOI: 10.1021/ac1023843
BAI YALONG, XIAO YI, SUO YUJUAN, SHEN YUANYUAN, SHAO YI, ZHANG DONGLAI, ZHOU CHANGYAN: "Enhancement of PCR Sensitivity and Yield Using Thiol-modified Primers", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 8, no. 1, US , XP093148726, ISSN: 2045-2322, DOI: 10.1038/s41598-018-33223-2
TANG JIN-BAO; YANG HONG-MING; GAO XIAO-YI; ZENG XIAN-ZHONG; WANG FENG-SHAN: "Directional immobilization of antibody onto magnetic nanoparticles by Fc-binding protein-assisted photo-conjugation for high sensitivity detection of antigen", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 1184, 11 September 2021 (2021-09-11), AMSTERDAM, NL , XP086814883, ISSN: 0003-2670, DOI: 10.1016/j.aca.2021.339054
ISABEL GESSNER, XIAOJIE YU, CHRISTIAN JüNGST, ANNIKA KLIMPEL, LINGYU WANG, THOMAS FISCHER, INES NEUNDORF, ASTRID C. SCHAUSS, : "Selective Capture and Purification of MicroRNAs and Intracellular Proteins through Antisense-vectorized Magnetic Nanobeads", SCIENTIFIC REPORTS, vol. 9, no. 1, 1 December 2019 (2019-12-01), XP055748898, DOI: 10.1038/s41598-019-39575-7
BAI YALONG, XIAO YI, SUO YUJUAN, SHEN YUANYUAN, SHAO YI, ZHANG DONGLAI, ZHOU CHANGYAN: "Enhancement of PCR Sensitivity and Yield Using Thiol-modified Primers", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 8, no. 1, US , XP093148726, ISSN: 2045-2322, DOI: 10.1038/s41598-018-33223-2
TANG JIN-BAO; YANG HONG-MING; GAO XIAO-YI; ZENG XIAN-ZHONG; WANG FENG-SHAN: "Directional immobilization of antibody onto magnetic nanoparticles by Fc-binding protein-assisted photo-conjugation for high sensitivity detection of antigen", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 1184, 11 September 2021 (2021-09-11), AMSTERDAM, NL , XP086814883, ISSN: 0003-2670, DOI: 10.1016/j.aca.2021.339054
ISABEL GESSNER, XIAOJIE YU, CHRISTIAN JüNGST, ANNIKA KLIMPEL, LINGYU WANG, THOMAS FISCHER, INES NEUNDORF, ASTRID C. SCHAUSS, : "Selective Capture and Purification of MicroRNAs and Intracellular Proteins through Antisense-vectorized Magnetic Nanobeads", SCIENTIFIC REPORTS, vol. 9, no. 1, 1 December 2019 (2019-12-01), XP055748898, DOI: 10.1038/s41598-019-39575-7
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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