Title:
MALIGNANT TUMOR METASTASIS INHIBITORS
Document Type and Number:
WIPO Patent Application WO/1997/024126
Kind Code:
A1
Abstract:
Drugs containing compounds represented by general formula (I) wherein R1 represents -O-R2, -S-R2, -CH2-R2 or -CH=R2, wherein R2 represents a C1-10 hydrocarbon chain optionally substituted by one or more hydroxyl groups, which are useful as a malignant tumor metastasis inhibitor without showing any particularly serious side effect.
Inventors:
OGATA ETSURO (JP)
IKEDA KYOJI (JP)
ENDO KOICHI (JP)
IKEDA KYOJI (JP)
ENDO KOICHI (JP)
Application Number:
PCT/JP1996/003874
Publication Date:
July 10, 1997
Filing Date:
December 27, 1996
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
OGATA ETSURO (JP)
IKEDA KYOJI (JP)
ENDO KOICHI (JP)
OGATA ETSURO (JP)
IKEDA KYOJI (JP)
ENDO KOICHI (JP)
International Classes:
A61K31/59; A61K31/593; (IPC1-7): A61K31/59
Other References:
THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 262, No. 9, (1987), RENNY T. FRANCESCHI et al., "Regulation of Cellular Adhesion and Fibronection Synthesis by 1a, 25-Dihydroxyvitamin D3", pages 4166-4171.
CANCER IMMUNOL. IMMUNOTHER, 41, (1995), M. RITA, I. YOUNG et al., "Treating Tumor-bearing Mice With Vitamin D3 Diminishes Tumor-induced Myelopoiesis and Associated Immunosuppression and Reduces Tumor Metastasis and Recurrence", pages 37-45.
THE JAPANESE JOURNAL OF CHEMICAL MEDICINE, Vol. 53, No. 7, July 1995, MOTOO NAKAJIMA, "Molecular Mechanism of Cancerous Metastasis", pages 7(1563)-14(1570).
ONCOLOGIA, Vol. 26, No. 1, SHOICHI SUDO, "Metastasis Suppression by Neovascularization Inhibitor TNP-470", pages 39-44.
ANTI-CANCER DRUGS, 2, TSUTOMU OIKAWA et al., "Antitumor Effect of 22-Oxa-1a, 25-Dihydroxyvitamin D3, a Potent Angiogenesis Inhibitor, on Rat Mammary Tumors Induced by 7,12-Dimethylbenz(a) Anthracene", pages 475-480.
CANCER IMMUNOL. IMMUNOTHER, 41, (1995), M. RITA, I. YOUNG et al., "Treating Tumor-bearing Mice With Vitamin D3 Diminishes Tumor-induced Myelopoiesis and Associated Immunosuppression and Reduces Tumor Metastasis and Recurrence", pages 37-45.
THE JAPANESE JOURNAL OF CHEMICAL MEDICINE, Vol. 53, No. 7, July 1995, MOTOO NAKAJIMA, "Molecular Mechanism of Cancerous Metastasis", pages 7(1563)-14(1570).
ONCOLOGIA, Vol. 26, No. 1, SHOICHI SUDO, "Metastasis Suppression by Neovascularization Inhibitor TNP-470", pages 39-44.
ANTI-CANCER DRUGS, 2, TSUTOMU OIKAWA et al., "Antitumor Effect of 22-Oxa-1a, 25-Dihydroxyvitamin D3, a Potent Angiogenesis Inhibitor, on Rat Mammary Tumors Induced by 7,12-Dimethylbenz(a) Anthracene", pages 475-480.
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