MALONIC DIAMIDE DERIVATIVES AND USE THEREOF

Title:

MALONIC DIAMIDE DERIVATIVES AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/1998/035939

Kind Code:

A1

Abstract:

Malonic diamide derivatives represented by general formula (I) and nontoxic salts thereof, having a cholesterol acyl transferase inhibitory activity, wherein R1, R2, and R3 represent each a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R4 and R5 represent each a hydrogen atom or a lower alkyl group; R6 and R7 represent each a hydrogen atom, a lower alkyl group, or an optionally substituted phenyl group; R8, R9 and R10 represent each a hydrogen atom, a halogen atom, a lower alkyl group, an optionally halogen-substituted lower alkoxy group, a lower alkyl-substituted amino group, a cyclic amino group, a lower alkylthio group, or a nitro group; X represents a bond or a methylene group; Y represents a bond, O, S, NR11, CHR11, or CH=CH, wherein R11 represents a lower alkyl group or a phenyl group; and n is an integer of 0, 1, 2 or 3.

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Inventors:

SUZUKI TOMOO (JP)
NAKAMURA SHIGEYOSHI (JP)
FUKUSHIMA MASATO (JP)
MINETA KOUJI (JP)
FUCHIGAMI MASAHIRO (JP)
MAEDA KOJI (JP)
KIMURA HIROMOTO (JP)
YAMAGUCHI KATSUSHI (JP)
MITANI TAKAHIKO (JP)

Application Number:

PCT/JP1997/003863

Publication Date:

August 20, 1998

Filing Date:

October 24, 1997

Export Citation:

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Assignee:

SANWA KAGAKU KENKYUSHO CO (JP)
SUZUKI TOMOO (JP)
NAKAMURA SHIGEYOSHI (JP)
FUKUSHIMA MASATO (JP)
MINETA KOUJI (JP)
FUCHIGAMI MASAHIRO (JP)
MAEDA KOJI (JP)
KIMURA HIROMOTO (JP)
YAMAGUCHI KATSUSHI (JP)
MITANI TAKAHIKO (JP)

International Classes:

C07D209/08; C07D215/08; C07D217/06; C07D223/16; C07D241/42; C07D265/36; C07D267/14; C07D281/10; (IPC1-7): C07D209/36; A61K31/40; A61K31/425; A61K31/47; A61K31/535; A61K31/54; A61K31/55; C07D215/08; C07D215/18; C07D215/20; C07D215/24; C07D223/16; C07D265/36; C07D267/14; C07D277/64; C07D277/66; C07D277/68; C07D279/16; C07D281/02

Foreign References:

JPH04236268A	1992-08-25
JPH03220164A	1991-09-27

Attorney, Agent or Firm:

Sasaki, Isao (2-29 Toranomon 1-chom, Minato-ku Tokyo 105, JP)

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