Title:
MAMMALIAN EXPRESSION SYSTEMS FOR HEPATITIS C VIRUS ENVELOPE GENES
Document Type and Number:
WIPO Patent Application WO1995020664
Kind Code:
A3
Abstract:
Mammalian expression systems for the production of HCV E1-E2 fusion proteins. Such expression systems provide high yields of HCV proteins extracelluarly, and enable the development of diagnostic, vaccine and therapeutic reagents which contain glycosylated structural antigens and also allow for the isolation of the HCV etiological agent.
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Inventors:
WATANABE SHINICHI
YAMAGUCHI JULIE
DESAI SURESH M
DEVARE SUSHIL G
YAMAGUCHI JULIE
DESAI SURESH M
DEVARE SUSHIL G
Application Number:
PCT/US1995/001087
Publication Date:
December 28, 1995
Filing Date:
January 27, 1995
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
G01N33/576; A61K39/29; A61K39/395; A61P31/12; C07H21/04; C07K14/18; C07K14/47; C07K16/08; C07K19/00; C12N15/09; C12P21/02; A61K39/00; (IPC1-7): C12N15/57; C12N15/62; G01N33/576
Domestic Patent References:
| WO1993015193A1 | 1993-08-05 | |||
| WO1992008734A1 | 1992-05-29 | |||
| WO1993021303A2 | 1993-10-28 | |||
| WO1993004088A1 | 1993-03-04 |
Foreign References:
| CA2098253A1 | 1993-12-12 |
Other References:
Q.-L- CHOO ET AL.;: "Genetic organization and diversity of the hepatitis C virus", PROC. NATL. ACAD. SCI. USA, vol. 88, pages 2451 - 2455
G. INCHAUSPE ET AL.;: "Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates", PROC. NATL. ACAD. SCI. USA, vol. 88, pages 10292 - 10296
H. HADA ET AL.;: "Detection by Western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease", ACTA MED. OKAYAMA, vol. 46, pages 365 - 370
EUR. J. CLIN. INVEST., vol. 23 (Suppl. 1) (1993), page A15, abstract no. 73, T. GOESER ET AL.;'Analysis of immune response of patients against the HCV E1 and E2 ...'
M. HOUGHTON ET AL.;: "Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral diseases", HEPATOLOGY, vol. 14, pages 381 - 388
G. INCHAUSPE ET AL.;: "Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates", PROC. NATL. ACAD. SCI. USA, vol. 88, pages 10292 - 10296
H. HADA ET AL.;: "Detection by Western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease", ACTA MED. OKAYAMA, vol. 46, pages 365 - 370
EUR. J. CLIN. INVEST., vol. 23 (Suppl. 1) (1993), page A15, abstract no. 73, T. GOESER ET AL.;'Analysis of immune response of patients against the HCV E1 and E2 ...'
M. HOUGHTON ET AL.;: "Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral diseases", HEPATOLOGY, vol. 14, pages 381 - 388
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