Title:
MAMMALIAN GENES AND GENE PRODUCTS INVOLVED IN INFECTION
Document Type and Number:
WIPO Patent Application WO/2013/066442
Kind Code:
A3
Abstract:
The present disclosure relates to mammalian genes and gene products that are involved in infection or are otherwise associated with the life cycle of one or more pathogens. Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include HIV-1, HIV-2, influenza A, Marburg virus and Ebola virus. The disclosure also relates to methods of identifying agents involved in pathogen infection.
Inventors:
HODGE THOMAS W (US)
MCDONALD NATALIE J (US)
MURRAY JAMES L (US)
SHAW MICHAEL W (US)
RUBIN DONALD H (US)
SANCHEZ ANTHONY (US)
MCDONALD NATALIE J (US)
MURRAY JAMES L (US)
SHAW MICHAEL W (US)
RUBIN DONALD H (US)
SANCHEZ ANTHONY (US)
Application Number:
PCT/US2012/048507
Publication Date:
July 18, 2013
Filing Date:
July 27, 2012
Export Citation:
Assignee:
HODGE THOMAS W (US)
MCDONALD NATALIE J (US)
MURRAY JAMES L (US)
SHAW MICHAEL W (US)
RUBIN DONALD H (US)
SANCHEZ ANTHONY (US)
MCDONALD NATALIE J (US)
MURRAY JAMES L (US)
SHAW MICHAEL W (US)
RUBIN DONALD H (US)
SANCHEZ ANTHONY (US)
International Classes:
A61K31/00; A61K31/7088; C12N15/113
Foreign References:
| US20060257872A1 | 2006-11-16 |
Other References:
KRISHNAN ET AL.: "Rab 5 is required for the cellular entry of dengue and West Nile viruses.", J. VIROL., vol. 81, no. 9, 2007, pages 4881 - 4885
Attorney, Agent or Firm:
BRADLEY, Karri, Kuenzli (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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