Title:
MAMMALIAN TRIBBLES SIGNALING PATHWAYS AND METHODS AND REAGENTS RELATED THERETO
Document Type and Number:
WIPO Patent Application WO2002053743
Kind Code:
A3
Abstract:
The invention provides methods and reagents for modulating mitogen activated protein kinase pathways using mammalian tribbles homologs (htrb).
Inventors:
DOWER STEVEN (GB)
QUANSTROM EVA (GB)
KISS-TOTH ENDRE (GB)
QUANSTROM EVA (GB)
KISS-TOTH ENDRE (GB)
Application Number:
PCT/US2002/000070
Publication Date:
October 09, 2003
Filing Date:
January 08, 2002
Export Citation:
Assignee:
INTERLEUKIN GENETICS INC (US)
DOWER STEVEN (GB)
QUANSTROM EVA (GB)
KISS-TOTH ENDRE (GB)
DOWER STEVEN (GB)
QUANSTROM EVA (GB)
KISS-TOTH ENDRE (GB)
International Classes:
A61K31/7088; A61K38/00; A61K45/00; A61K48/00; A61P1/04; G01N33/50; A61P17/06; A61P25/28; A61P29/00; A61P43/00; C07H21/04; C07K14/47; C07K14/54; C12N5/10; C12N15/09; C12N15/10; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; G01N33/53; G01N37/00; (IPC1-7): C12N15/12; C07K14/47; C12N15/11; C12Q1/68; G01N33/50
Other References:
DATABASE EMBL [online] 3 December 2000 (2000-12-03), MAYHAUS ET AL.: "Homo sapiens G-protein-coupled receptor induced protein GIG2 mRNA, complete cds.", XP002217012, Database accession no. AF205437
DATABASE EMBL [online] 20 September 2000 (2000-09-20), SUGANO ET AL.: "Homo sapiens cDNA: FLJ23292 fis, clone HEP10334.", XP002217013, Database accession no. AK026945
DATABASE SWALL [online] 1 October 2000 (2000-10-01), BLAKEY S: "Novel protein kinase domains containing protein similar to phosphoprotein C8FW and rat NIPK.", XP002217014, Database accession no. Q9NUD2
DATABASE SWALL [online] 1 February 1997 (1997-02-01), OHNO ET AL.: "Homo sapiens GS3955 protein.", XP002217015, Database accession no. Q92519
RORTH PERNILLE ET AL: "The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.", MOLECULAR CELL, vol. 6, no. 1, July 2000 (2000-07-01), pages 23 - 30, XP002217009, ISSN: 1097-2765
ONDREY FRANK G ET AL: "Constitutive activation of transcription factors NF-kappaB, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines.", MOLECULAR CARCINOGENESIS, vol. 26, no. 2, October 1999 (1999-10-01), pages 119 - 129, XP001117625, ISSN: 0899-1987
HAN SEUNG H ET AL: "Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 287, no. 3, December 1998 (1998-12-01), pages 1105 - 1112, XP002217011, ISSN: 0022-3565
DATABASE EMBL [online] 20 September 2000 (2000-09-20), SUGANO ET AL.: "Homo sapiens cDNA: FLJ23292 fis, clone HEP10334.", XP002217013, Database accession no. AK026945
DATABASE SWALL [online] 1 October 2000 (2000-10-01), BLAKEY S: "Novel protein kinase domains containing protein similar to phosphoprotein C8FW and rat NIPK.", XP002217014, Database accession no. Q9NUD2
DATABASE SWALL [online] 1 February 1997 (1997-02-01), OHNO ET AL.: "Homo sapiens GS3955 protein.", XP002217015, Database accession no. Q92519
RORTH PERNILLE ET AL: "The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.", MOLECULAR CELL, vol. 6, no. 1, July 2000 (2000-07-01), pages 23 - 30, XP002217009, ISSN: 1097-2765
ONDREY FRANK G ET AL: "Constitutive activation of transcription factors NF-kappaB, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines.", MOLECULAR CARCINOGENESIS, vol. 26, no. 2, October 1999 (1999-10-01), pages 119 - 129, XP001117625, ISSN: 0899-1987
HAN SEUNG H ET AL: "Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells.", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 287, no. 3, December 1998 (1998-12-01), pages 1105 - 1112, XP002217011, ISSN: 0022-3565
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