Title:
MANNOSE-6-PHOSPHATE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO2004104015
Kind Code:
A3
Abstract:
Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.
Inventors:
COWDEN WILLIAM (AU)
BARTELL GAVIN (AU)
ESCHLER BART (AU)
MARCH DARREN (AU)
ROBERTSON ALAN (AU)
BARTELL GAVIN (AU)
ESCHLER BART (AU)
MARCH DARREN (AU)
ROBERTSON ALAN (AU)
Application Number:
PCT/US2004/015876
Publication Date:
March 24, 2005
Filing Date:
May 20, 2004
Export Citation:
Assignee:
COWDEN WILLIAM (AU)
BARTELL GAVIN (AU)
ESCHLER BART (AU)
MARCH DARREN (AU)
ROBERTSON ALAN (AU)
BARTELL GAVIN (AU)
ESCHLER BART (AU)
MARCH DARREN (AU)
ROBERTSON ALAN (AU)
International Classes:
A61P29/00; C07F9/00; C07H11/04; (IPC1-7): C07H11/04; A61P29/00
Domestic Patent References:
| WO2002004472A1 | 2002-01-17 |
Foreign References:
| AU4186697A | 1998-04-23 | |||
| US6140307A | 2000-10-31 |
Other References:
BARRAGAN ET AL.: "A mannose-6-phosphonate-cholesterylamine conjugate as a specific molecular adhesive linking cancer cells with vesicles", CHEM. COMM., 2001, pages 85 - 86, XP002301443
VIDIL ET AL.: "Synthèse de mannose 6-phosphonates, analogues isostères du mannose 6-phosphate", PHOSPHOROUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 158, 2000, pages 125 - 139, XP009038355
VIDIL ET AL.: "Synthèse de mannose 6-phosphonates, analogues isostères du mannose 6-phosphate", PHOSPHOROUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 158, 2000, pages 125 - 139, XP009038355
Download PDF: