Title:
MANNOSE 6-PHOSPHATE ISOMERASE, MUTANTS THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/049409
Kind Code:
A2
Abstract:
The present invention relates to a novel mannose 6-phosphate isomerase enzyme, mutants thereof, and a method of manufacturing L-ribose with such mutant enzymes. More particularly, the invention relates to mannose 6-phosphate isomerase enzymes and variants thereof, recombinant expression vectors containing expression genes thereof, microorganisms transformed to express such genes, manufacturing methods for producing large quantities of mannose 6-phosphate isomerase enzyme and its mutants, and production methods for high yields of L-ribose made with the mannose 6-phosphate isomerase mutant enzymes.
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Inventors:
OH DEOK KUN (KR)
YEOM SOO JIN (KR)
YEOM SOO JIN (KR)
Application Number:
PCT/KR2010/007295
Publication Date:
April 28, 2011
Filing Date:
October 22, 2010
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
OH DEOK KUN (KR)
YEOM SOO JIN (KR)
OH DEOK KUN (KR)
YEOM SOO JIN (KR)
International Classes:
C12N9/90; C12N15/61; C12P19/02
Other References:
DATABASE PROTEIN 23 May 2009 'putative mannose-6-phosphate isomerase [Thermus thermophilus HB8]' Database accession no. BAD71168
YEOM, S. ET AL.: 'Characterization of a mannose-6-phosphate isomerase from Geobacillus thermodenitrificans that converts monosaccharides' BIOTECHNOLOGY LETTER. vol. 31, no. 8, 24 April 2009, pages 1273 - 1278
YEOM, S. ET AL.: 'Substract specificity of a mannose-6-phosphate isomerase from Bacillus subtilis and its application in the production of L-ribose' APPLIED AND ENVIRONMENTAL MICROBIOLOGY. vol. 75, 15 May 2009, pages 4705 - 4710
YEOM, S. ET AL.: 'Characterization of a mannose-6-phosphate isomerase from Thermus thermophilus and increased L-ribose production by its R142N mutant' APPLIED AND ENVIRONMENTAL MICROBIOLOGY. vol. 77, 29 November 2010, pages 762 - 767
YEOM, S. ET AL.: 'Molecular characterization of a novel thermostable mannose-6-phosphate isomerase from Thermus thermophilus' BIOCHIMIE. vol. 93, no. 10, 26 June 2011, pages 1659 - 1667
YEOM, S. ET AL.: 'Characterization of a mannose-6-phosphate isomerase from Geobacillus thermodenitrificans that converts monosaccharides' BIOTECHNOLOGY LETTER. vol. 31, no. 8, 24 April 2009, pages 1273 - 1278
YEOM, S. ET AL.: 'Substract specificity of a mannose-6-phosphate isomerase from Bacillus subtilis and its application in the production of L-ribose' APPLIED AND ENVIRONMENTAL MICROBIOLOGY. vol. 75, 15 May 2009, pages 4705 - 4710
YEOM, S. ET AL.: 'Characterization of a mannose-6-phosphate isomerase from Thermus thermophilus and increased L-ribose production by its R142N mutant' APPLIED AND ENVIRONMENTAL MICROBIOLOGY. vol. 77, 29 November 2010, pages 762 - 767
YEOM, S. ET AL.: 'Molecular characterization of a novel thermostable mannose-6-phosphate isomerase from Thermus thermophilus' BIOCHIMIE. vol. 93, no. 10, 26 June 2011, pages 1659 - 1667
Attorney, Agent or Firm:
KOO, Hyun Seo (KR)
구현서 (KR)
구현서 (KR)
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